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  1. Contents (click topic) • Employment numbers (life sciences) • Health sector activities • Types of work environments • Research • Production • Quality Assurance / Control • Health companies • Health research • Chemical and Bioscience Technology

  2. Employment • Life sciences sector: ~ 4,200 employees • 41 companies (17 agri-food, 22 biomedical, 2 environmental) • 2300 are in 5 companies (Cangene, Biovail, Apotex, Monsanto & VitaHealth) • 30 research and development establishments employ 1900 people • There are 23 service firms that support the life sciences industries.

  3. Life Science Activities • Pharmaceutical research & production • Infectious diseases • Cardiovascular diseases • Cancer / oncology / child health • Non-invasive biodiagnostics • Molecular biology, Mapping & Gene Cloning • Proteomics & Bioinformatics

  4. Life Science Activities • Bacterial Fermentation & Metabolic Engineering • Marker-assisted Gene Selection • Proteomics • Level 3 & 4 Bio-containment • Biological Mass Spectrometry • Role of nutrition in health

  5. Work Environment Three Main Areas: • R&D – Research and Development • Production • QA/QC – Quality Assurance / Quality Control

  6. Research Team • Works in a laboratory environment • Find product / idea with value • Characterize: composition, potency, etc. • Establish product specifications • Develop analytical / manufacture methods • Microbiological considerations • Raw materials & equipment specifications

  7. Research Jobs • Scientist • Research Scientist • Research Associate • Research Technician • Laboratory Technician • Laboratory Scientist • Media Preparation Technician

  8. Production Team • Works in a Production (GMP) facility • Makes the product – biochemical, etc. • Work with large volumes / equipment • Routine operation, cleaning, calibration and maintenance of equipment • Monitoring and control • Follow SOP (standard operating procedure) • Complete forms, labels, log-books (GMP)

  9. Production Jobs • Manufacturing Operator • Manufacturing Technician • Manufacturing Supervisor • Production Technician • Pilot Plant Operator • Pilot Plant Technician

  10. QA / QC Team • Works in office, lab and inspects facility • Monitor equipment, facilities, personnel, product • Review all production procedures • Ensures document / record accuracy • Test samples of product and raw materials • Compare results to established standards • Approve product release

  11. QC / QA Jobs • Quality Assurance Technician • Quality Control Technician • Assay Analyst • Documentation Specialist • Compliance Specialist • Internal Auditor

  12. Work Environment Life Sciences = Regulated Industries • Strict controls for materials affecting human health • Facilities have to meet exact requirements • Methods have to be inspected and approved (Health Canada, FDA, etc.) • People have to trained, tested and authorized to participate

  13. Work Environment Academic / Gov. Research • University or Research Organization lab • Investigate fundamental problems in biology / chemistry (etc.) • “Product” is knowledge or information • Research may have to be validated following GLP / ISO • Can require degree(s)

  14. Work Environment R&D Laboratories in Industry • Work in-house laboratory (small / large) • Investigate with intent of a commercial product, conduct scale-up / pilot plant • Focused, aggressive, highly effective • Work conducting following recognized protocols: ISO, GLP, etc. • Require diploma / degree

  15. Work Environment Production Facilities • Warehouse-scale manufacturing operations • May be highly sanitary • May be noisy and damp • Can be simple job or highly complex • Entry from college / high school

  16. Work Environment Testing Labs (QA, Microbiol, Clinical) • Independent or governmental labs • Perform tests on samples / devices • May be highly routine • May be occasionally variable • Facility is often certified GLP / ISO • Diploma / degree required

  17. Health Companies

  18. Health Companies Apotex Fermentation Inc. • AFI uses fermentation-based technologies for the production of Active Pharmaceutical Ingredients (APIs). • The Winnipeg facility is the largest fermentation-based GMP facility in Canada.

  19. Health Companies Biovail Corporation • Formulation, clinical testing, & manufacturing of pharmaceutical products. • Biovail has operations in the US and Canada, and a research facility in Ireland.

  20. Health Companies Medicure Inc. • Development of drugs for cardiovascular diseases and stroke. • The company's lead product, MC-1, reduces ischemic injury caused by restrictions in blood flow.

  21. Manitoba Research

  22. Infectious Diseases Canadian Science Centre for Human and Animal Health (CSCHAH) • A leading research location for infectious disease • Study human pathogens & zoonotic diseases, prion diseases, influenza virus, enterics, STDs, hepatitis, tuberculosis, genomics, antimicrobial resistance, & foreign animal diseases.

  23. Infectious Diseases Canadian Science Centre for Human and Animal Health • The laboratory is the first and only global centre with level-4 bio-containment capabilities for the study of both human and animal diseases.

  24. Cardiovascular Institute of Cardiovascular Sciences • Involved in drug discoveries for the treatment of heart failure, ischemic heart disease, and diabetes. • Located at the St. Boniface General Hospital Research Centre

  25. Nutrimedicine National Centre for Agri-food Research Within St. Boniface General Hospital Research Centre • Studies health-related benefits of natural health products • Evaluates health benefits, medical side effects, & athletic performance through research and clinical trials.

  26. Clinical Trials I.H. Asper Clinical Research Institute • Links basic medical research programs at the St. Boniface General Hospital Research Centre with patient care. • Conducts Phase I and Phase II clinical trials on cutting edge pharmaceuticals for heart disease & stroke.

  27. Medical Diagnostics Institute for Biodiagnostics (IBD) • The National Research Council's IBD investigates instrumentation and methods for noninvasive diagnosis of serious health conditions (cancer, arthritis, heart disease, neurological conditions, and osteoporosis). • Has the largest concentration of MRIs and NMRs for R&D purposes in Canada.

  28. Child Health Manitoba Institute of Child Health • Dedicated to pediatric research • Has expertise in developmental pharmacology, respirology, genetics, and toxicology.

  29. Oncology CancerCare Manitoba • A key R&D facility (HSC) involved with the prevention, care, and research of cancer • Recently constructed a $3 million breast cancer research facility (HSC) • Also involved with Radiation Protection consultations and measurement services.

  30. Oncology Manitoba Institute of Cell Biology • Studies the molecular origins of cancer and the role of signal transduction pathways in regulating cell proliferation. • Also involved in developing markers of risk of developing invasive breast cancer

  31. Oncology Genomic Centre for Cancer Research and Diagnosis (GCCRD) • Conducts research in genomic instability and mechanisms of neoplasia (formation of new tissue). • GCCRD is part of the Manitoba Institute of Cell Biology (MICB), CancerCare Manitoba, and the University of Manitoba.

  32. Oncology Mammalian Functional Genomics Centre • Creates diverse human disease models in mice, for rapid assessment of gene function. • Created a library of mouse embryonic stem cells, each with a defined mutation in a cellular gene to help disease modeling

  33. Proteomics Manitoba Centre for Proteomics • Analyzes human inflammatory diseases using proteomic approaches and identifies biomarkers for these diseases. • The Centre is partnered with Applied Biosystems, Ciphergen Biosystems, and Chemicon International Corp.

  34. Proteomics Biomedical Proteomics Program, University of Manitoba • The Biomedical Proteomics Program seeks to connect basic biological, agricultural and biomedical scientists with those scientists developing instrumentation and analytical software.

  35. 32,000 students, 110-plus programs • Applied Biopharmaceutical Processing • Applied Biology • Applied Chemistry • Applied Pharmaceutics • Chemical and Biosciences Tech Co-op • Environmental Protection Technology • Medical Laboratory Sciences • Medical Radiologic Technology • MRI and Spectroscopy • QA/QC in Pharmaceutical Industry

  36. Chemical and Biosciences Technology • 2-year applied program at RRC • Features: • Co-op job placement • Exceptional laboratory training • Provides skills employers want • Enormous range of grad opportunities • Joint 4-year degree program with UW

  37. Additional Resources • Bioscience Websites - David Blicq / RRC • Science Job postings • Manitoba Bioscience news • Course summaries and lab manuals • Resumé and Cover letters • On-line courses (viewable content)

  38. Additional Resources • Other Content: • Study skills for science • Employer-requested skill-sets • Interview tips • Lab documentation GLP / ISO • Student pages

  39. Manitoba Science Opportunity & Innovation