Contents (click topic) • Employment numbers (life sciences) • Health sector activities • Types of work environments • Research • Production • Quality Assurance / Control • Health companies • Health research • Chemical and Bioscience Technology
Employment • Life sciences sector: ~ 4,200 employees • 41 companies (17 agri-food, 22 biomedical, 2 environmental) • 2300 are in 5 companies (Cangene, Biovail, Apotex, Monsanto & VitaHealth) • 30 research and development establishments employ 1900 people • There are 23 service firms that support the life sciences industries.
Life Science Activities • Pharmaceutical research & production • Infectious diseases • Cardiovascular diseases • Cancer / oncology / child health • Non-invasive biodiagnostics • Molecular biology, Mapping & Gene Cloning • Proteomics & Bioinformatics
Life Science Activities • Bacterial Fermentation & Metabolic Engineering • Marker-assisted Gene Selection • Proteomics • Level 3 & 4 Bio-containment • Biological Mass Spectrometry • Role of nutrition in health
Work Environment Three Main Areas: • R&D – Research and Development • Production • QA/QC – Quality Assurance / Quality Control
Research Team • Works in a laboratory environment • Find product / idea with value • Characterize: composition, potency, etc. • Establish product specifications • Develop analytical / manufacture methods • Microbiological considerations • Raw materials & equipment specifications
Research Jobs • Scientist • Research Scientist • Research Associate • Research Technician • Laboratory Technician • Laboratory Scientist • Media Preparation Technician
Production Team • Works in a Production (GMP) facility • Makes the product – biochemical, etc. • Work with large volumes / equipment • Routine operation, cleaning, calibration and maintenance of equipment • Monitoring and control • Follow SOP (standard operating procedure) • Complete forms, labels, log-books (GMP)
Production Jobs • Manufacturing Operator • Manufacturing Technician • Manufacturing Supervisor • Production Technician • Pilot Plant Operator • Pilot Plant Technician
QA / QC Team • Works in office, lab and inspects facility • Monitor equipment, facilities, personnel, product • Review all production procedures • Ensures document / record accuracy • Test samples of product and raw materials • Compare results to established standards • Approve product release
QC / QA Jobs • Quality Assurance Technician • Quality Control Technician • Assay Analyst • Documentation Specialist • Compliance Specialist • Internal Auditor
Work Environment Life Sciences = Regulated Industries • Strict controls for materials affecting human health • Facilities have to meet exact requirements • Methods have to be inspected and approved (Health Canada, FDA, etc.) • People have to trained, tested and authorized to participate
Work Environment Academic / Gov. Research • University or Research Organization lab • Investigate fundamental problems in biology / chemistry (etc.) • “Product” is knowledge or information • Research may have to be validated following GLP / ISO • Can require degree(s)
Work Environment R&D Laboratories in Industry • Work in-house laboratory (small / large) • Investigate with intent of a commercial product, conduct scale-up / pilot plant • Focused, aggressive, highly effective • Work conducting following recognized protocols: ISO, GLP, etc. • Require diploma / degree
Work Environment Production Facilities • Warehouse-scale manufacturing operations • May be highly sanitary • May be noisy and damp • Can be simple job or highly complex • Entry from college / high school
Work Environment Testing Labs (QA, Microbiol, Clinical) • Independent or governmental labs • Perform tests on samples / devices • May be highly routine • May be occasionally variable • Facility is often certified GLP / ISO • Diploma / degree required
Health Companies Apotex Fermentation Inc. • AFI uses fermentation-based technologies for the production of Active Pharmaceutical Ingredients (APIs). • The Winnipeg facility is the largest fermentation-based GMP facility in Canada.
Health Companies Biovail Corporation • Formulation, clinical testing, & manufacturing of pharmaceutical products. • Biovail has operations in the US and Canada, and a research facility in Ireland.
Health Companies Medicure Inc. • Development of drugs for cardiovascular diseases and stroke. • The company's lead product, MC-1, reduces ischemic injury caused by restrictions in blood flow.
Infectious Diseases Canadian Science Centre for Human and Animal Health (CSCHAH) • A leading research location for infectious disease • Study human pathogens & zoonotic diseases, prion diseases, influenza virus, enterics, STDs, hepatitis, tuberculosis, genomics, antimicrobial resistance, & foreign animal diseases.
Infectious Diseases Canadian Science Centre for Human and Animal Health • The laboratory is the first and only global centre with level-4 bio-containment capabilities for the study of both human and animal diseases.
Cardiovascular Institute of Cardiovascular Sciences • Involved in drug discoveries for the treatment of heart failure, ischemic heart disease, and diabetes. • Located at the St. Boniface General Hospital Research Centre
Nutrimedicine National Centre for Agri-food Research Within St. Boniface General Hospital Research Centre • Studies health-related benefits of natural health products • Evaluates health benefits, medical side effects, & athletic performance through research and clinical trials.
Clinical Trials I.H. Asper Clinical Research Institute • Links basic medical research programs at the St. Boniface General Hospital Research Centre with patient care. • Conducts Phase I and Phase II clinical trials on cutting edge pharmaceuticals for heart disease & stroke.
Medical Diagnostics Institute for Biodiagnostics (IBD) • The National Research Council's IBD investigates instrumentation and methods for noninvasive diagnosis of serious health conditions (cancer, arthritis, heart disease, neurological conditions, and osteoporosis). • Has the largest concentration of MRIs and NMRs for R&D purposes in Canada.
Child Health Manitoba Institute of Child Health • Dedicated to pediatric research • Has expertise in developmental pharmacology, respirology, genetics, and toxicology.
Oncology CancerCare Manitoba • A key R&D facility (HSC) involved with the prevention, care, and research of cancer • Recently constructed a $3 million breast cancer research facility (HSC) • Also involved with Radiation Protection consultations and measurement services.
Oncology Manitoba Institute of Cell Biology • Studies the molecular origins of cancer and the role of signal transduction pathways in regulating cell proliferation. • Also involved in developing markers of risk of developing invasive breast cancer
Oncology Genomic Centre for Cancer Research and Diagnosis (GCCRD) • Conducts research in genomic instability and mechanisms of neoplasia (formation of new tissue). • GCCRD is part of the Manitoba Institute of Cell Biology (MICB), CancerCare Manitoba, and the University of Manitoba.
Oncology Mammalian Functional Genomics Centre • Creates diverse human disease models in mice, for rapid assessment of gene function. • Created a library of mouse embryonic stem cells, each with a defined mutation in a cellular gene to help disease modeling
Proteomics Manitoba Centre for Proteomics • Analyzes human inflammatory diseases using proteomic approaches and identifies biomarkers for these diseases. • The Centre is partnered with Applied Biosystems, Ciphergen Biosystems, and Chemicon International Corp.
Proteomics Biomedical Proteomics Program, University of Manitoba • The Biomedical Proteomics Program seeks to connect basic biological, agricultural and biomedical scientists with those scientists developing instrumentation and analytical software.
32,000 students, 110-plus programs • Applied Biopharmaceutical Processing • Applied Biology • Applied Chemistry • Applied Pharmaceutics • Chemical and Biosciences Tech Co-op • Environmental Protection Technology • Medical Laboratory Sciences • Medical Radiologic Technology • MRI and Spectroscopy • QA/QC in Pharmaceutical Industry
Chemical and Biosciences Technology • 2-year applied program at RRC • Features: • Co-op job placement • Exceptional laboratory training • Provides skills employers want • Enormous range of grad opportunities • Joint 4-year degree program with UW
Additional Resources • Bioscience Websites - David Blicq / RRC • Science Job postings • Manitoba Bioscience news • Course summaries and lab manuals • Resumé and Cover letters • On-line courses (viewable content)
Additional Resources • Other Content: • Study skills for science • Employer-requested skill-sets • Interview tips • Lab documentation GLP / ISO • Student pages
Manitoba Science Opportunity & Innovation