Enhancing Granulation with Robust and Efficient High-Shear Mixers (1)

1. Enhancing Granulation with Robust and Efficient High-Shear Mixers Granulation directly impacts the quality, stability, consistency and performance of the final product in pharma and chemical manufacturing. The key to effective granulation is two critical factors: process robustness and high efficiency. While there are different methods to achieve granulation, high-shear mixers stand out for their efficiency and robustness. Most pharma nd nutraceutical manufacturers opting for consistent and robust granules choose this granulation equipment. In this blog, we have explained what high-shear mixers are and where they fit in your tablet manufacturing process. This blog is a decision-enabling piece. So keep reading till the end. What are high-shear mixer granulators for pharma?

2. High-shear mixer granulators, also known as rapid mixer granulators, are machines that convert fine powders into uniform granules. They are specifically designed to meet these needs, offering superior mixing capabilities within a short timeframe and providing a wide process window in terms of mixing duration. The technology behind high-shear granulators works: High-shear granulators for pharma rely on a mix of shear, impact, compression, and binder-driven cohesion to transform fine powders into strong, uniform granules suitable for tablets. Because of their fast and efficient mixing and granulation, they got the name Rapid Mixer Granulator. During operations, powders (API + excipients) are loaded. Two components are responsible for uniform, dense and free-flowing granules with this granulation equipment: ● Impeller: Blends API and excipients, distributes the binder solution and initiates granule formulation. ● Chopper: Spins at high speed to break down lumps and control particle size. Once the desired size and moisture are reached, the batch is discharged for drying. Key Features of High-Shear Mixer Granulators ● Cross-contamination protection: Equipped with an impeller and chopper shaft purging system, these mixers utilize inflatable seals and interlocking devices to prevent cross-contamination, ensuring product integrity. ● Flexible Charging Options: Depending on product characteristics, these mixers offer flexible charging options, including pneumatic systems and gravity charging, to suit various production needs. ● Flexibility and Scalability: High Shear Granulator for small-scale use (lab or pilot batches) High Shear Granulator for large-scale production (commercial manufacturing).

3. The F plus series of high-shear mixer granulators supports scalability, seamlessly transitioning from R&D stages to pilot and full-scale production. This series accommodates a wide range of volumes, from 0.5 liters to 1200 liters, making it suitable for various production scales. Key Benefits: These rapid mixer granulators are preferred by tablet manufacturers because: ● Higher Yields: These mixers are engineered to prevent wall caking and clogging. This design ensures controlled discharging, contributing to robust and secure processing. ● High Batch Variability: The unique positioning and geometry of the mixing tools, along with versatile operating modes, allow for varying filling levels from 20% to 80%, accommodating different batch sizes with ease. Read More: Why Invest In A State-Of-The-Art Granulator Machine For Pharmaceuticals Application: High-shear mixer granulators excel in producing high-quality granules with enhanced flowability and optimized particle size distribution. As a core equipment for wet granulation in pharma tablet production, they ensure superior product quality across different applications.

4. They are ideal for manufacturing: ● Powders ● Granules ● Pellets What makes the high shear mixer granulator by F Plus Healthcare stand out for pharmaceutical applications? F Plus is among the top high-shear granulator manufacturers in India, helping pharma companies build businesses that can meet the evolving demands of the industry. F+ Healthcare has a plethora of granulator machines for pharmaceutical companies. Our high shear mixer granulators are preferred because of: ● Advanced drive design: Name it as: integrated wet mill F Plus high shear mixer granulator features a direct drive system delivering over 95% torque transmission to the impeller blades, ensuring accurate end-point detection. It also includes an integrated wet comill at discharge for efficient milling of the wet mass. ● Safe and compliant:

5. Our high-shear mixers adhere to the latest CE and ATEX directives and comply with current Good Manufacturing Practices (GMP) standards, ensuring safety and regulatory compliance. ● Customizable: With years of experience in the field, we are renowned high shear granulator manufacturers in India, especially for engineering pharma equipment according to the process needs. Our mixers are highly customizable to meet the specific needs and requirements of end users, providing tailored solutions for diverse manufacturing challenges. Conclusion A high shear granulator is a critical piece of pharma equipment for ensuring consistent, high-quality medicines. But the final output is only as good as the equipment you use. That’s why it’s important to research carefully and select a rapid mixer granulator manufacturer that matches your specific application needs. F Plus Healthcare Technologiesis a trusted pharma equipment manufacturer, chosen by companies across India that prioritize patient care. H1 - Enhancing Granulation with Robust and Efficient High-Shear Mixers Meta title - Efficient High-Shear Mixers for Enhanced Granulation | F Plus

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