Endocrine Physiology lecture 3. Dale Buchanan Hales, PhD Department of Physiology & Biophysics. Anterior pituitary. Anterior pituitary : connected to the hypothalamus by hypothalmoanterior pituitary portal vessels. The anterior pituitary produces six peptide hormones:
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Dale Buchanan Hales, PhD
Department of Physiology & Biophysics
A prominent feature of each of the hormonal sequences initiated by the hypothalamic releasing hormones is negative feedback exerted upon the hypothalamic-pituitary system by the hormones whose production are stimulated in the sequence.
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Harvey Cushing’s first reported case
Identical twins, 22 years old, excess GH secretion
Processing and cleavage of pro-opiomelanocortin (POMC)
Glycoprotein hormones contain two subunits, a common a subunit and a distinct b subunit: TSH, LH, FSH and hCG.