Endocrine Control of Gastrointestinal Function
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Endocrine Control of Gastrointestinal Function. Jack L. Leonard 2004. GI Hormones. Candidate Hormones. Neurocrines. Volume Secreted during first 2 hrs. 150. total. 100. 25. cephalic. gastric. 50. total. 20. intestinal. cephalic. 15. Volume (ml/15 min). 10. gastric. 5.

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Endocrine control of gastrointestinal function

Volume Secreted

during first 2 hrs

150

total

100

25

cephalic

gastric

50

total

20

intestinal

cephalic

15

Volume (ml/15min)

10

gastric

5

intestinal

1

2

3

4

Hours

Fed meat

The Three Phases of Acid Secretion


Endocrine control of gastrointestinal function

+

sight, smell

taste, chewing

swallowing

conditioned reflex

Acetylcholine

Bombesin

-

+

+

-

Somatostatin

+

gastrin

H+

Cephalic Phase

Vagal nucleus

Somatostatin

cell

G-cell

Oxyntic

cell


Endocrine control of gastrointestinal function

local

reflex

acetylcholine

Stomach

distention

Vago-

vagal

reflex

gastrin

bombesin

Peptides

Amino

acids

Protein

digestion

acetylcholine

H+

Gastric Phase


Endocrine control of gastrointestinal function

Intestinal

G Cell

Gastrin

Protein

Digestion

products

Intestinal

Endocrine

Cell

Entero-

oxyntin

H+

Absorbed amino acids

Intestinal Phase



Endocrine control of gastrointestinal function

Factors Regulating Acid Secretion

Conditioned stimuli

Smell, taste

Chewing

Swallowing

hypoglycemia

Vagus nerve

Gastrin

G cell

H20 &

HCO3-

AcH

AcH

Acinar cells

Duct cells

Enzymes

Gastrin


Endocrine control of gastrointestinal function

Vagus nerve

(vagovagal reflex)

Parietal cell

Fat

Protein

H+

E cells

CCK

Peptides + Amino acids

Fat

S cells

H+

Secretin

Duct

cells

H20 &

HCO3-

Acinar

cells

AcH

AcH

Enzymes

Secretin

CCK

Factors Regulating Acid Secretion (cont)


Endocrine control of gastrointestinal function

Pre-Prandial

Pancreas

Post-Prandial

Monitor peptide

Food Protein

Chymotrypsin

Trypsin

Small intestine

CCK

Pancreatic Enzyme Secretion


Endocrine control of gastrointestinal function

Gut – Insulin Secretion

Neural reflexes

Intestinal dose

Oral dose

40

100

Insulin (mU/ml

Insulin (mU/ml

50

20

0

0

4

8

40

1

20

min

min

10% glucose

10% glucose

100

100

0

0

5 min