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Metabolism of nucleotides

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  1. Metabolism of nucleotides Richard Vytášek 2011

  2. Introduction • Structure of nucleobases, nucleosides and nucleotides • Metabolic functions effected by nucleotides • Dietetary uptake of nucleotides and their utilization

  3. Biosynthesis of nucleotides • Biosynthesis of purine nucleotides de novo (PRPP -> IMP -> AMP, GMP) and its regulation • Purine salvage pathway (Lesch-Nyhan Syndrom) • Biosynthesis of pyrimidine nucleotides de novo and its regulation • Pyrimidine salvage pathway • Biosynthesis of deoxyribonucleotides • Biosynthesis of thymine nucleotides

  4. Catabolism of nucleotides and nucleobases • Degradation of nucleotides • Degradation of purine nucleotides • Gout • Degradation of pyrimidine nucleotides • Degradation of thymine

  5. Nucleoside analogues • antiviral agents (typically inhibitors of reverse transcriptase – e.g. azidothymidine ) • cytostatics (chemotherapy – e.g. cytosine arabinoside )

  6. Literature Harper´s Illustrated Biochemistry (2006) pp. 294-310