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Chemistry 910 Practical Medicinal Chemistry. Dr John Carran Queen’s University Department of Chemistry. Background. In conjunction with Dale Cameron To develop a course to teach the fundamentals of medicinal chemistry and then to apply them Lecture component Practical component.

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chemistry 910 practical medicinal chemistry

Chemistry 910Practical Medicinal Chemistry

Dr John Carran

Queen’s University

Department of Chemistry

background
Background
  • In conjunction with Dale Cameron
  • To develop a course to teach the fundamentals of medicinal chemistry and then to apply them
  • Lecture component
  • Practical component
lecture component
Lecture component
  • Where do drugs act
  • How do drugs bind
  • How are drugs metabolised/consequences
  • How are drugs administered/consequences
  • How are drugs tested
  • SAR/QSAR
  • Molecular modeling (Mike Kuiper, Melbourne, Australia)
  • Lead compound generation/drug design
  • Chemistry and improving activity/drug design
  • Business/intellectual property (Angela Lyon, Parteq, Queen’s University)
  • Process/scale up
  • Clinical trials
  • Case studies
practical component
Practical component
  • Aim: To mimic an industrial lead compound selection process. Opiate analgesics.
  • Each week for 5 weeks a series of compounds with associated data is released.
  • Each “company” must select one compound to progress in their pipeline to lead compound designation
  • Each company must rationalise their selection process to a Medicinal Chemistry mentor.
mentors
Mentors
  • Dale Cameron - Migenix Corp
  • Jack Bikker –Wyeth Research
  • Harold Mastalertz – BMS
  • Sheldon Hiebert – BMS
  • Sheldon Crane – Merck

Dinesh Vyas

Rick Friesen

video conferencing
Video conferencing
  • One per week, weeks 7-11
  • Skype or VSee (Free!)
  • Each “company” has 30 minutes
  • Questions from mentor on selection process / red herrings
  • Teaching component
  • Evaluations on “company” and individual members returned to me
course breakdown
Course breakdown
  • Take home assignment (mechanism question in synthesis of Artemisinin) and “midterm” week 6 (handout) (50%)
  • Videoconferencing assignments (5), weeks 7-11 (25% total)
  • Professional project report week 9 (5%)
  • Final poster presentation week 12 (20%)
aims of marked component
Aims of marked component
  • Midterm exam- examines lecture component material
  • Videoconferencing – communication, rationale, comprehension
  • Report – communication, comprehension
  • Poster presentation – future work, innovation
current enrollment
Current enrollment
  • Six students
  • 3 companies (teams) of two students
  • 5 chemists, 1 pharmacologist
  • Ideal enrollment 12+ of mixed groups (chemist + pharmacologist + biochemist)
acknowledgements
Acknowledgements
  • QCIC
  • Dale Cameron, Dinesh Vyas, Rick Friesen, Jack Bikker
  • Harold Mastalertz, Sheldon Hiebert, Sheldon Crane
  • Angela Lyon, Michael Kuiper
  • Caitlin Latimer (SWEP program, Queen’s University)
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