university of louisville
Download
Skip this Video
Download Presentation
University of Louisville

Loading in 2 Seconds...

play fullscreen
1 / 28

University of Louisville - PowerPoint PPT Presentation


  • 98 Views
  • Uploaded on

University of Louisville. The Department of Bioinformatics and Biostatistics. Faculty. Guy Brock, PhD, Assistant Professor Somnath Datta, PhD, Professor Susmita Datta, PhD, Associate Professor L. Jane Goldsmith, PhD, Associate Professor Maiying Kong, PhD, Assistant Professor

loader
I am the owner, or an agent authorized to act on behalf of the owner, of the copyrighted work described.
capcha
Download Presentation

PowerPoint Slideshow about ' University of Louisville' - zena-odonnell


An Image/Link below is provided (as is) to download presentation

Download Policy: Content on the Website is provided to you AS IS for your information and personal use and may not be sold / licensed / shared on other websites without getting consent from its author.While downloading, if for some reason you are not able to download a presentation, the publisher may have deleted the file from their server.


- - - - - - - - - - - - - - - - - - - - - - - - - - E N D - - - - - - - - - - - - - - - - - - - - - - - - - -
Presentation Transcript
university of louisville

University of Louisville

The Department of Bioinformatics and Biostatistics

slide2

Faculty

  • Guy Brock, PhD, Assistant Professor
  • Somnath Datta, PhD, Professor
  • Susmita Datta, PhD, Associate Professor
  • L. Jane Goldsmith, PhD, Associate Professor
  • Maiying Kong, PhD, Assistant Professor
  • Steven J. McCabe, MD, MSc, Assistant Professor
  • John A. Myers, PhD, Assistant Professor
  • Rudolph S. Parrish, PhD, Professor and Chair
  • Shesh Rai, PhD, Associate Professor
  • Dongfeng Wu, PhD, Associate Professor
  • Jae Keun Yoo, PhD, Assistant Professor
slide3

Programs and Initiatives

  • Masters in Public Health – concentration in Biostatistics
  • Biostatistics M.S. and Ph.D.
  • Decision Science M.S. and Ph.D.
  • Bioinformatics (upcoming)
  • Cancer Biostatistics (upcoming)
  • Collaborative Research
  • Statistical Consulting Center
slide4

Current Degree Programs

Students

  • MPH 2
  • MS
    • Biostatistics 7
    • Decision science 1
  • Ph.D.
    • Biostatistics 15
    • Decision science 1
master of public health
Master of Public Health
  • Nationally-known faculty
  • Leading-edge information technologies
  • Challenging, real-world experiences
  • A dynamic collaboration with the Louisville Metro Health Department provides first-hand opportunities to address public health challenges in a top-20 U.S. city
what is biostatistics
What is biostatistics?
  • Biostatistics involves the development and application of statistical techniques to scientific research in health-related fields, including medicine, epidemiology, and public health.

From http://www.amstat.org/Careers/copss/index.cfm?fuseaction=biostatistics

slide7

Biostatisticians

  • Government
    • Federal
    • State
    • Local
  • Industry
    • Drug and device development
    • CRO’s
  • Research institutions
    • Grants funded through NIH and other agencies
  • Self-employed
    • Contract work
salaries for ph d biostatisticians beginning faculty careers
Salaries for Ph.D. Biostatisticians Beginning Faculty Careers

(1-3 years experience)

  • 25th percentile: $ 82,400
  • 50th percentile: $ 85,000
  • 75th percentile: $90,000
what is bioinformatics
What is Bioinformatics?
  • The science of informatics as applied to biological research.
  • Informatics is the management and analysis of data using advanced computing techniques.
  • Statisticians are supposed to be experts in analyzing data
what kind of data
What kind of data?

Usually, in bioinformatics we deal with genomics, proteomics or metabolomics data.

Example: Microarray data, Mass Spectrometry data and high dimensional data from different metabolites.

dna microarray
DNA Microarray
  • A DNA microarray (or "chip") enables the geneticist to monitor the expression patterns of numerous genes (potentially all of the genes in a given cell type) at the same time.

Example:

Finding genes/biomarkers for cancer

  • Identify the set of genes that are “differentially expressed” between normal and cancer cells
  • microarray experiment among two (or more) cell types

e.g., 1 = normal cell; 2 = cancer cell

cdna microarray
cDNA microarray

Data: log (R / G)

analyzing microarray data
Analyzing Microarray Data:
  • Goal: to find differentially expressed genes
  • Problem: obscure variability mixed with true
  • Solution (using Statistics!)
slide23

Biological question

Differentially expressed genes

Sample class prediction etc.

Experimental design

Microarray experiment

16-bit TIFF files

Image analysis

(Rfg, Rbg), (Gfg, Gbg)

Normalization

R, G

Estimation

Testing

Clustering

Discrimination

Biological verification

and interpretation

decision science
Decision Science
  • Understanding decision making in the context of public health
    • To understand how decisions are made
    • To improve decision making
    • To study specific decision making problems
slide25
Combination of clinical research methodology, biostatistics, and psychology
  • All of these areas of interest have an impact on clinical decision making
decision analysis
Decision Analysis
  • An explicit process to understand a decision and make the best decision in the face of uncertainty.
decision science courses at sphis
Decision Science Courses at SPHIS
  • Introduction to Medical Decision Making
  • Advanced Medical Decision Making
  • Decision Analysis (Speed School)
  • Utility Theory and Measurement
  • Cost-Effectiveness Analysis
links of interest
Links of Interest
  • Department of Bioinformatics and Biostatistics
    • http://louisville.edu/sphis/bb
  • American Statistical Association
    • http://www.amstat.org
  • Society for Medical Decision Making
    • www.smdm.org
ad