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University of Louisville. The Department of Bioinformatics and Biostatistics. Faculty. Guy Brock, PhD, Assistant Professor Somnath Datta, PhD, Professor Susmita Datta, PhD, Associate Professor L. Jane Goldsmith, PhD, Associate Professor Maiying Kong, PhD, Assistant Professor

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University of louisville

University of Louisville

The Department of Bioinformatics and Biostatistics


Faculty

  • Guy Brock, PhD, Assistant Professor

  • Somnath Datta, PhD, Professor

  • Susmita Datta, PhD, Associate Professor

  • L. Jane Goldsmith, PhD, Associate Professor

  • Maiying Kong, PhD, Assistant Professor

  • Steven J. McCabe, MD, MSc, Assistant Professor

  • John A. Myers, PhD, Assistant Professor

  • Rudolph S. Parrish, PhD, Professor and Chair

  • Shesh Rai, PhD, Associate Professor

  • Dongfeng Wu, PhD, Associate Professor

  • Jae Keun Yoo, PhD, Assistant Professor


Programs and Initiatives

  • Masters in Public Health – concentration in Biostatistics

  • Biostatistics M.S. and Ph.D.

  • Decision Science M.S. and Ph.D.

  • Bioinformatics (upcoming)

  • Cancer Biostatistics (upcoming)

  • Collaborative Research

  • Statistical Consulting Center


Current Degree Programs

Students

  • MPH 2

  • MS

    • Biostatistics 7

    • Decision science 1

  • Ph.D.

    • Biostatistics 15

    • Decision science 1


Master of public health
Master of Public Health

  • Nationally-known faculty

  • Leading-edge information technologies

  • Challenging, real-world experiences

  • A dynamic collaboration with the Louisville Metro Health Department provides first-hand opportunities to address public health challenges in a top-20 U.S. city


What is biostatistics
What is biostatistics?

  • Biostatistics involves the development and application of statistical techniques to scientific research in health-related fields, including medicine, epidemiology, and public health.

    From http://www.amstat.org/Careers/copss/index.cfm?fuseaction=biostatistics


Biostatisticians

  • Government

    • Federal

    • State

    • Local

  • Industry

    • Drug and device development

    • CRO’s

  • Research institutions

    • Grants funded through NIH and other agencies

  • Self-employed

    • Contract work


Salaries for ph d biostatisticians beginning faculty careers
Salaries for Ph.D. Biostatisticians Beginning Faculty Careers

(1-3 years experience)

  • 25th percentile: $ 82,400

  • 50th percentile: $ 85,000

  • 75th percentile: $90,000



What is bioinformatics
What is Bioinformatics? Careers

  • The science of informatics as applied to biological research.

  • Informatics is the management and analysis of data using advanced computing techniques.

  • Statisticians are supposed to be experts in analyzing data


What kind of data
What kind of data? Careers

Usually, in bioinformatics we deal with genomics, proteomics or metabolomics data.

Example: Microarray data, Mass Spectrometry data and high dimensional data from different metabolites.


Dna microarray
DNA Microarray Careers

  • A DNA microarray (or "chip") enables the geneticist to monitor the expression patterns of numerous genes (potentially all of the genes in a given cell type) at the same time.

    Example:

    Finding genes/biomarkers for cancer

  • Identify the set of genes that are “differentially expressed” between normal and cancer cells

  • microarray experiment among two (or more) cell types

    e.g., 1 = normal cell; 2 = cancer cell


Cdna microarray
cDNA microarray Careers

Data: log (R / G)


Analyzing microarray data
Analyzing Microarray Data: Careers

  • Goal: to find differentially expressed genes

  • Problem: obscure variability mixed with true

  • Solution (using Statistics!)


Biological question Careers

Differentially expressed genes

Sample class prediction etc.

Experimental design

Microarray experiment

16-bit TIFF files

Image analysis

(Rfg, Rbg), (Gfg, Gbg)

Normalization

R, G

Estimation

Testing

Clustering

Discrimination

Biological verification

and interpretation


Decision science
Decision Science Careers

  • Understanding decision making in the context of public health

    • To understand how decisions are made

    • To improve decision making

    • To study specific decision making problems



Decision analysis
Decision Analysis and psychology

  • An explicit process to understand a decision and make the best decision in the face of uncertainty.


Decision science courses at sphis
Decision Science Courses at SPHIS and psychology

  • Introduction to Medical Decision Making

  • Advanced Medical Decision Making

  • Decision Analysis (Speed School)

  • Utility Theory and Measurement

  • Cost-Effectiveness Analysis


Links of interest
Links of Interest and psychology

  • Department of Bioinformatics and Biostatistics

    • http://louisville.edu/sphis/bb

  • American Statistical Association

    • http://www.amstat.org

  • Society for Medical Decision Making

    • www.smdm.org


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