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BIOCHEMISTRY

BIOCHEMISTRY. 生物化学. 万晴姣 School of biological technology and engineering. 教 材: 《 biochemistry》（ 第二版，影印版） Reginald H. Garrett & Charles M.Grisham 高等教育出版社 主要参考书目: 1．《生物化学》（第三版） 王镜岩主编 高等教育出版社 2. 《生物化学》（上、下册） 沈彤，王镜岩主编 高等教育出版社

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BIOCHEMISTRY

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  1. BIOCHEMISTRY 生物化学 万晴姣 School of biological technology and engineering

  2. 教 材: 《biochemistry》（第二版，影印版）Reginald H. Garrett & Charles M.Grisham 高等教育出版社 主要参考书目: 1．《生物化学》（第三版） 王镜岩主编 高等教育出版社 2. 《生物化学》（上、下册） 沈彤，王镜岩主编 高等教育出版社 3．《Instant Notes in Biochemistry》（第二版，先锋版） B.D.Hames & N.M.Hopper 科学出版社 4．《普通生物化学》（第三版） 郑集，陈钧辉编著 高等教育出版社

  3. 生物化学是生命的化学，是研究微生物、动物、植物和人体的化学以及生命过程中化学变化的一门科学。

  4. The Early Years • Antoin Lavoisier (1743-1794) • Joseph Louis Gay-Lussac (1778-1850) • Friederich Wohler 1828 H2N-CO-NH2 • Hoppe Seyler 1877 (Zeitschrift fur Physiologesche Chemie ) • Carl A. Neuberg 1903 biochemistry • W. Kuhne enzyme • Emil Fischer 1894 enzyme specificity

  5. II. Rapid Progress in Biochemistry • 1926 James B. Summer urease • 1937 Hans A. Krebs TCA cycle • 1951 Linus Pauling & Robert Corey a-helix • 1953 Frederich Sanger insulin • 1953 James D. Watson & Francis H.C. Crick DNA double-helix

  6. Part I . Molecular Components of Cell

  7. Chapter 4 Amino Acids

  8. 4.1 Amino Acids: Building Blocks of Proteins 4.1.1 Common Amino Acids

  9. Nonpolar Amino Acids Ala Val Leu Ile Pro Met Phe Try • Polar,Uncharged Amino Acids Gly Ser Thr Cys Asn Gln Tyr • Acidic Amino Acids Asp Glu Lys Arg His • Basic Amino Acids

  10. 4.1.2 Uncommon Amino Acids

  11. 4.1.3 Amino Acids Not Found in Proteins

  12. 4.2 Acid-Base Chemistry of Amino Acids

  13. (pI)

  14. (pI) (pI)

  15. 4.3 Reactions of Amino Acids 4.3.1 Carboxyl and Amino Group Reactions

  16. 4.3.2 The Ninhydrin Reaction

  17. 4.3.3 Specific Reaction of Amino Acid Side Chains

  18. 4.4 Optical Activity and Stereochemistry of Amino Acids

  19. 4.5 Spectroscopic Properties of Amino Acids • Ultraviolet Spectra 280nm

  20. Nuclear Magnetic Resonance (NMR) Spectra

  21. 4.6 Separation and Analysis of Amino Acid Mixtures Chromatographic Methods • Ion Exchange Chromatographic • Gas Chromatographic (GC) • High-performance Liquid Chromatographic (HPLC)

  22. Operation of a cation exchange column ,separating a mixture of Asp,Ser,and Lys.

  23. The separation of amino acid on a cation exchange column.

  24. HPLC

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