1 / 28

Meningitis: The role of climate for prediction Andy Morse Ph.D. Department of Geography University of Liverpool A.P.Mors

Meningitis: The role of climate for prediction Andy Morse Ph.D. Department of Geography University of Liverpool A.P.Morse@liv.ac.uk. Mark Cresswell Ph.D EGS Manchester Metropolitan University. 1.0 Background. Meningococcal Meningitis .

yorick
Download Presentation

Meningitis: The role of climate for prediction Andy Morse Ph.D. Department of Geography University of Liverpool A.P.Mors

An Image/Link below is provided (as is) to download presentation Download Policy: Content on the Website is provided to you AS IS for your information and personal use and may not be sold / licensed / shared on other websites without getting consent from its author. Content is provided to you AS IS for your information and personal use only. Download presentation by click this link. While downloading, if for some reason you are not able to download a presentation, the publisher may have deleted the file from their server. During download, if you can't get a presentation, the file might be deleted by the publisher.

E N D

Presentation Transcript


  1. Meningitis: The role of climate for prediction Andy Morse Ph.D. Department of Geography University of Liverpool A.P.Morse@liv.ac.uk Mark Cresswell Ph.D EGS Manchester Metropolitan University

  2. 1.0 Background Meningococcal Meningitis • Bacterial meningitis (Neisseria meningitidis) causes epidemics • 12 serotypes are know only 4 cause epidemics A, B, C and W135 • Group A generally causes epidemics in Africa although cases due to serogroups C, X and W135 are found. • B and C are more common in the U.K. • Vaccines exist for A, C, X, Y and W135

  3. 1.1 Background Meningococcal Meningitis • Transmitted person to person (sneezing, coughing, kissing) (military recruits, students) • Average period of incubation 4 days ( 2 to 10days) • Estimated 10 to 25% carry the bacterial but can increase in epidemics • U.K. matter of education and seeking treatment

  4. 1.2 Background Meningococcal Meningitis in Africa • Meningitis epidemic disease, highly seasonal - later half dry season • Epidemics every 5 to 10 years – kills young adults as well as children • Climatic connections are ‘not proven’ - low humidity (vapour pressure) and dust important factors • Epidemics cease with the onset of the rains Figure from Cheesbrough,JS, Morse AP, Green SDR. Meningococcal meningitis and carriage in western Zaire: a hypoendemic zone related to climate? Epidemiology and Infection 1995: 114; 75-92

  5. 1.3 Background West African Climate • Area dominated by seasonal rains produced by a monsoonal system • Strong latitudinal gradient in ‘wetness’ and thus climates and vegetation • Monsoon system is complex and not well understood • Leads to large interannual climate

  6. 1.4 Background West Africa Atlas

  7. 1.5 Background West African Climate • Monsoon System and AMMA experiments

  8. 1.6 Background West African Climate NDVI February NDVI August From MARA eshaw website http://www.mara.org.za/eshaw.htm

  9. 1.7 Background Look at Hutchinson rainfall climate maps in unit folder West African Climate Animation from University of Liverpool Understanding Epidemics Website http://www.liv.ac.uk/geography/research_projects/epidemics/MAL_intro.htm Data from CLIVAR VACS Africa Climate Atlas at University of Oxford

  10. 1.10 Background Epidemic Cycles • Many infectious diseases, in the tropics, have a strong seasonal cycle related to the seasonal climatic cycles • Climatically anomalous years can lead to epidemics • Time between trigger threshold to epidemic peak often too short to take effective intervention – need for skilful and timely seasonal climate forecast Vaccine Effect Threshold

  11. 2.0 Linking climate to disease Spatial Distribution Meningitis Epidemics 1841-1999 (n = c.425) 1 Example for meningitis in Africa • Extensive literature search was undertaken to identify reported epidemics • Published and grey literature were consulted 1 Molesworth A.M., Thomson M.C., Connor S.J., Cresswell M.P., Morse A.P., Shears P., Hart C.A., Cuevas L.E. (2002) Where is the Meningitis Belt?, Transactions of the Royal Society of Hygiene and Tropical Medicine, 96, 242-249.

  12. 2.1 Linking climate to disease Example for meningitis in Africa • Statistical Model to produce a map of risk • Epidemiological data and climatic and environmental variables • Risk factors: • Land cover type and seasonal absolute humidity profile • Seasonal dust profile, Population density, Soil type • Significant but not included in final model • Human factors not included Molesworth, A.M., Cuevas,L.E., Connor, S.J., Morse A.P., Thomson, M.C. (2003). Environmental risk and meningitis epidemics in Africa, Emerging Infectious Diseases, 9 (10), 1287-1293.

  13. 2.2 Linking climate to disease Example for meningitis in Africa • Cluster analysis to define areas with common seasonal cycle • Absolute humidity values • Used to produce risk map shown above Molesworth, A.M., Cuevas,L.E., Connor, S.J., Morse A.P., Thomson, M.C. (2003). Environmental risk and meningitis epidemics in Africa, Emerging Infectious Diseases, 9 (10), 1287-1293.

  14. 2.4 Linking climate to disease Values to give an absolute humidity of about 10 gm-3

  15. 2.6 Linking climate to disease Example for meningitis in Africa • Disease is complex and dry air and dust are not the only factors • Many human ones – immunity, nutrition and co-infection • However the environmental variables may lead to the population becoming more susceptible • The environmental variables may be predictable months in advance.

  16. 3.0 Potential of Seasonal Forecasting Background and applications • Probabilistic forecasts are made routinely • Statistical models – more established – more regionally and single variable orientated – cannot work outside their training data – can work well e.g. spring SST to summer rains (West Africa) • Dynamic models – Ensemble Prediction Systems – experimental also operational too • Loaded dice example – loading and hence predictability changes with time and location

  17. 3.1 Potential of Seasonal Forecasting Dynamic EPS products • Typical Products from ECMWF

  18. 3.2 Potential of Seasonal Forecasting Dynamic EPS products • Typical Products from ECMWF Probabilistic Seasonal 2 to 4 month lead time

  19. 3.3 Potential of Seasonal Forecasting Combined products International Research Institute for Climate Prediction (IRI), Columbia University, New York Seasonal Forecast 2 to 4 month lead time

  20. 3.4 Potential of Seasonal Forecasting Dynamic EPS – issues for users and producers • Tailored verification • Verification of user parameters • Scale – downscaling • Bias correction • Weighting • Application model and method development – run with EPS • Product derived time scale cut off – medium, monthly, seasonal and beyond • Interdisciplinary nature of research • Taking of academic risk

  21. 3.5 Potential of Seasonal Forecasting Product Verification yellow through red - increasing predictive skillwhite through dark blue - little or no better than guesswork Units = Gerrity skill score Met. Office Seasonal Forecast Precip. AMJ 2 to 4 month lead time

  22. 3.8 Potential of Seasonal Forecasting Liverpool Malaria Model – LMM • Dynamic model • Daily time step • Driven by temperature and precipitation • Observations, reanalysis, ensemble prediction systems • Developed within a probabilistic forecasting system – DEMETER • Continuing in EMSEMBLES • Model details Hoshen, M.B.and Morse, A.P. (2004) A weather-driven model of malaria transmission, Malaria Journal, 3:32 (6th September 2004) doi:10.1186/1475-2875-3-32 (14 pages) • Applied in an EPS in Morse, A.P., Doblas-Reyes, F., Hoshen, M.B., Hagedorn, R. and Palmer, T.N.(2005). A forecast quality assessment of an end-to-end probabilistic multi-model seasonal forecast system using a malaria model, Tellus A, 57 (3), 464-475

  23. 4.0 Summary The Forecasting Triangle Providers Users Dissemination Feedback Forecasts Demand Training + Product Guidance and Development Developers with users and providers

  24. 4.1 Summary • Probabilistic (and deterministic) forecasts are routinely produced operationally leads times days to seasons • This potential resource is under utilised by application user communities- gaps in knowledge and awareness issues with forecast skill and guidance in products lack of user application know how and appropriate user application models

  25. 4.3 Summary Current and recent research projects • DEMETER EU FP5 ENSEMBLES EU FP6 Addressing development and application of ensemble prediction systems • AMMA-EU FP6, AMMA-UK NERC, West African monsoon observations, modelling impacts

  26. 5.0 Conclusions Infectious diseases must be modelled to allow use within emerging long range forecast technologies. Much has been done to bridge gaps between forecaster and health user but still many gaps Work is on going and a new ‘epimeteorology’ community is emerging

  27. Websites • WHO meningitis site http://www.who.int/mediacentre/factsheets/fs141/en/ • Meningitis Research Foundation http://www.meningitis.org/ • EU and NERC funded AMMA improve ability to predict the West African Monsoon and its impacts on intra-seasonal to decadal timescales. http://www.amma-eu.org/ and http://amma.mediasfrance.org/ • EU funded ENSEMBLES probabilistic forecasts of climate variability and climate change over timescales of seasons to centuries and the application and potential impacts of these predictions. http://www.ensembles-eu.org/ • Washington, R., Harrison, M, Conway, D., Black, E., Challinor, A., Grimes, D., Jones, R., Morse, A. and Todd, M (2004). African Climate Report - A report commissioned by the UK Government to review African climate science, policy and options for action, DFID/DEFRA, London, December 2004, pp45 http://www.defra.gov.uk/environment/climatechange/ccafrica-study/

More Related