Liver Alcohol Dehydrogenase: An Equal Opportunity Detoxifier of Organic Compounds, Toxins and Pollutants. A metal cation lowers the pKa of water coordinately bound to the metal ion providing a source of OH - . Ethanol. Acetaldehyde. Acetic Acid. Water originally coordinately bound to
Liver Alcohol Dehydrogenase:
An Equal Opportunity Detoxifier of Organic Compounds, Toxins and Pollutants
A metal cation lowers the pKa
of water coordinately bound to
the metal ion providing a source
“Principles of Bioinorganic Chemistry”, Lippard and Berg, University Science Books, Mill Valley, CA, 1994
~ Properties of Ethanol & its toxicity ~
Ethanol is a monohydric primary alcohol. It boils at 78.5° C. It is miscible (i.e., mixes without separation) with water in all proportions and is separated from water only with difficulty; Ethanol forms a constant-boiling mixture, or azeotrope, with water that contains 95% Ethanol and 5% water and that boils at 78.15° C; since the boiling point of this binary azeotrope is below that of pure Ethanol, absolute Ethanol cannot be obtained by simple distillation.
Clinical Effects of Ethanol: The effects of moderate alcohol consumption is well known to most people. Patients present with dis-coordination, and slurred speech. At high doses Ethanol is a general CNS depressant. Alcohol is broken down in the liver by alcohol dehydrogenase.
Medically, Ethanol is a soporific, i.e., sleep-producing; although it is less toxic than the other alcohols, death usually occurs if the concentration of Ethanol in the bloodstream exceeds about 5%. Behavioural changes, impairment of vision, or unconsciousness occur at lower concentrations. With levels as low as 50-100 mg/dl children can present with coma, hypothermia, and hypoglycaemia.
~ Methanol & its toxicity ~
Methanol itself may cause inebriation but by itself is almost completely non-toxic. The problem you see is methanol is metabolized by liver alcohol dehydrogenase also; to formaldehyde then to formic acid. It is these two metabolites that cause toxicity, with formic acid being more responsible. It is the formic acid that causes the profound metabolic acidosis that is typical of Methanol poisoning. The overall mortality of Methanol poisoning is approximately 20% and among survivors the rate of permanent visual impairment is 20-25%. Fatal dose 100ml.
Poisoning with Methanol may be accidental or intentional. There have been epidemics of Methanol toxicity in cases where illicit whiskey has been sold to large populations or when the less expensive Methanol was substituted for Ethanol in drinks.
Ethanol is used to decrease the metabolism of Methanol. Alcohol dehydrogenase acts to break down both Ethanol and Methanol, and is the rate limiting step in the metabolism. The enzyme, alcohol dehydrogenase, has a greater affinity for Ethanol than it does for Methanol. Therefore, in the presence of Ethanol, the metabolism of Methanol to its toxic metabolites is greatly slowed. It is appropriate to begin an Ethanol drip while awaiting blood levels of Methanol. Ethanol drips are also indicated if the blood Methanol level returns and is 20 mg/dl or above. The target Ethanol level is 100-150 mg/dl since this is the level that will saturate alcohol dehydrogenase.
The degree of toxicity correlates with the amount of methanol ingested, but not with presenting methanol levels. Latency between ingestion and toxicity occurs because of the time required to convert methanol to toxic metabolites. The toxic effects become apparent when LADH has metabolized methanol to formaldehyde. Formaldehyde is highly toxic but is rapidly degraded by aldehyde dehydrogenase and other nonspecific enzymes to formic acid, which is responsible for the metabolic acidosis and anion gap. Further metabolism of formic acid to carbon dioxide is dependent on folate.
Holistic Medicince.com states: Abuse of the Scientific Method Seen in Monsanto Aspartame Research in Collusion with the FDA and the Multiple Sclerosis Society
Subject: FW: Health information on ASPARTAME
WORLD ENVIRONMENTAL CONFERENCE and the MULTIPLE SCLEROSIS FOUNDATION F.D.A. ISSUING FOR COLLUSION WITH MONSANTO Article written by Nancy Markle (1120197)
I have spent several days lecturing at the WORLD ENVIRONMENTAL CONFERENCE on "ASPARTAME marketed as 'NutraSweet', 'Equal', and 'Spoonful"'. In the keynote address by the EPA, they announced that there was an epidemic of multiple sclerosis and systemic lupus, and they did not understand what toxin was causing this to be rampant across the United States.
I explained that I was there to lecture on exactly that subject. When the temperature of Aspartame exceeds 86 degrees F, the wood alcohol in ASPARTAME coverts to formaldehyde and then to formic acid, which in turn causes metabolic acidosis. (Formic acid is the poison found in the sting of fire ants). The methanol toxicity mimics multiple sclerosis; thus people were being diagnosed with having multiple sclerosis in error. The multiple sclerosis is not a death sentence, where methanol toxicity is.
Toxicity Effects of Aspartame Use
Selection of adverse effects from short-term and/or long-Term use
seizures and convulsions
migraines and severe headaches (Trigger or Cause From Chronic Intake)
memory loss (common toxicity effects)
slurring of speech
numbness or tingling of extremities
panic attacks (common aspartame toxicity reaction)
marked personality changes
rapid heart beat, tachycardia (another frequent reaction)
hypertension (high blood pressure)
nausea or vomitting
hives / urticaria
other allergic reactions
blood sugar control problems (e.g., hypoglycemia or hyperglycemia)
menstrual cramps and other menstraul problems or changes
impotency and sexual problems
hair loss / baldness or thinning of hair
burning urination & other urination problems
excessive thirst or excessive hunger
bloating, edema (fluid retention)
brain cancer (Pre-approval studies in animals)
Aspartame Disease Mimmicks Symptoms or Worsens the Following Diseases
multiple sclerosis (MS)
diabetes and diabetic Complications
chronic fatigue syndrome
multiple chemical sensitivities (MCS)
attention deficit disorder (ADD and ADHD)
depression and other psychological disorders