Causal reasoning in Biomedical Informatics. Chitta Baral Professor Department of Computer Science and Engineering [email protected] Causal connection versus Correlation. Rain, Falling Barometer: They usually have a 1-1 correspondence Does falling barometer cause rain?
Causal reasoning in Biomedical Informatics
Department of Computer Science and Engineering
treatment was given
treatment was not given
Suppose we have 3 variables A, B, and C obtained from the data that:
Think of A, B and C that satisfy the above.
Most likely your interpretation of A, B and C would satisfy the causal relations A B C as shown below.
Some necessary definitions
Necessary to state when the
Partial biological prior knowledge:
MMP3 is expected to be at the end of the pathway
Pirin causatively influences WNT5A –
“In order to maintain the level of
WNT5A we need to directly control
WNT5A or through pirin”.
Causal connection between WNT5A and
“WNT5A directly causes MART-1”
Proper function: The function that reflects the influence of the operators.
c = f(a,b) = (ab) (a b)
= a is not a proper function.
Recall = ATP/(AFN+ATP), Precision = ATP/(ATP + AFP)