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Enzyme Mechanisms

Enzyme Mechanisms. RNaseA Acid-Base Catalysis. 2. Amino Acid Decarboxylase Covalent Catalysis. http://cti.itc.virginia.edu/~cmg/Demo/scriptFrame.html. 3. Enolase Metal Ion Catalysis. 4. Lysozyme. “Phillips Mechanism”. 5. Serine Proteases acid/base + covalent catalysis. Examples:

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Enzyme Mechanisms

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  1. Enzyme Mechanisms

  2. RNaseA • Acid-Base Catalysis

  3. 2. Amino Acid DecarboxylaseCovalent Catalysis http://cti.itc.virginia.edu/~cmg/Demo/scriptFrame.html

  4. 3. EnolaseMetal Ion Catalysis

  5. 4. Lysozyme

  6. “Phillips Mechanism”

  7. 5. Serine Proteasesacid/base + covalent catalysis Examples: chymotrypsin trypsin subtilisin thrombin

  8. http://bmbiris.bmb.uga.edu/8010/moremen/weblinks/WebSerineProteases/SerProt.htmlhttp://bmbiris.bmb.uga.edu/8010/moremen/weblinks/WebSerineProteases/SerProt.html http://www.bio.cmu.edu/courses/03231/Protease/SerPro.htm http://wps.prenhall.com/wps/media/objects/726/744224/0120f.html

  9. Catalytic triad

  10. Peptide bond cleavage !

  11. 6. Aspartate Proteases Examples: Pepsin HIV protease http://cti.itc.virginia.edu/~cmg/Demo/scriptFrame.html

  12. HIV protease

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