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Kevin A. Negrete - President

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To live better - PowerPoint PPT Presentation


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Kevin A. Negrete - President. DNA Workshop (Bologna, Italy). To live better …. longer. To increase the quality of life after 40. Two main factors contributing longer (historical) lifespan. Two main factors contributing to limited lifespan. reduce cellular oxidation .

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to live better

To live better…

longer

To increase the quality of life after 40

slide9

reduce cellular oxidation

the formation of nascent oxygen (O2)

and the elimination of free radicals (O+)

slide11

Research has allowed scientists to identify central aging system in cells – and specifically the aging clock in DNA

The two basic DNA markers that regulate aging are

Telomere length and Methyl Group Loss

slide12

Telomere

Inside the center or nucleus of a cell, our genes are located on twisted, double-stranded molecules of DNA called chromosomes.

At the ends of the chromosomes are stretches of DNA called telomeres, which protect our genetic data, make it possible for cells to divide.

Telomeres have been compared with the plastic tips on shoelaces because they prevent chromosome ends from fraying and sticking to each other, which would scramble an organism\'s genetic information to cause cancer, other degenerative diseases, or death.

Each time a cell divides the telomeres get shorter (by 30-200 BP). Healthy cells only divide between 50-70 times. When telomeres get too short, the cells no longer can divide and becomes inactive, sustain genetic damage and ultimately die.

slide13

Similar to telomere shortening – the loss of Methyl Groups (CH3) shows a specific preprogrammed degradation throughout mammalian lifespan. The degradation is accelerated by oxidative stress, poor nutrition, lack of exercise, and environmental toxins.

H

H

H

H

H

H

H

H

H

slide14

Final Common Pathway of Aging – DNA Demethylation

10% loss

25 yrs

20% loss

50 yrs

30% loss

75 yrs

40% loss

Death

Birth

slide15

Understand true anti-aging (DNA) mammalian chemistry consists of 2 goals: elongate telomers and increase DNA methylation.

ENHANCED

NUCLEOTIDE

SUPPLEMENATION

slide16

Longevity of Control vs. Treated Animals

2500

2000

1500

1500

1000

750

150

750

750

Control

Treated

record mammalian longevity achieved through weekly injection of dna and rna
Record mammalian longevity achieved through weekly injection of DNA and RNA
  • Study began with 750 day old rats with usual longevity of 800 to 900 days
  • Identical conditions except treated animals received nucleic acid injections
  • Post 8 weeks control rats lost fur and vitality, whereas treated animals increased muscle mass, libido, and activity levels
  • Control animals all died in less than 150 days from start of study
  • Treated animals lived a minimum of 850 up to 1500 additional days from start of study, doubling and even tripling the usual life span
slide18

Understand true anti-aging (DNA) mammalian chemistry consists of 2 goals: elongate telomers and increase DNA methylation.

HOMOCYSTEINE

slide19

What is Homocysteine?

Homocysteine is a toxic amino acid by-product produced by our own organism and accumulates in the bloodstream.

Elevated homocysteine is not only the indicator of, but is the CAUSE of many major diseases includinAlzheimer’, Arthritis, Cancer, Chronic Fatigue, Depression, Diabetes, Heart Attacks, Infertility, Obesity, Strokes, Thyroid Problems, and Ulcers

Homocysteine also accelerates the oxidation of LDL

slide21

Research has shown that higher HOMOCYSTEINE levels are directly

related to demethylation and telomere shortening

3 ways to detoxify HOMOCYSTEINE

methyl group transfer metabolic pathways
Methyl Group Transfer Metabolic Pathways

Methionine

ATP

S-adenosyl-methionine (SAMe)

DMG

B12 Folic Acid

Betaine (TMG)

Donates CH3 to:

DNA

Proteins

Lipids

Carbohydrates

Myelin

Detox Pathways

Neurotransmitter Production

And others

S-adenosyl-homocysteine (SAH)

Choline

Homocysteine (Hcy)

Zn Vitamin B6

Cysteine

Glutathione

slide23

We have developed THE ENGINE OF REMETHYLATION

making cells younger through

Enhanced Nucleotide Supplementation

methyl group transfer metabolic pathways1
Methyl Group Transfer Metabolic Pathways

Methionine

ATP

S-adenosyl-methionine (SAMe)

DMG

B12 Folic Acid

Betaine (TMG)

Donates CH3 to:

DNA

Proteins

Lipids

Carbohydrates

Myelin

Detox Pathways

Neurotransmitter Production

And others

S-adenosyl-homocysteine (SAH)

Choline

Homocysteine (Hcy)

Zn Vitamin B6

Cysteine

Glutathione

slide25

Could life-extension and anti-aging be as simple as

supplying the body with DNA and RNA?

primary source of nucleotides is endogenous synthesis from amino acids and simple precursors
Primary source of nucleotides is endogenous synthesis from amino acids and simple precursors
  • Therefore nucleic acids have generally been considered nonessential nutrients
  • Under stress, however, some tissues unable to produce enough nucleotides to support tissue needs
  • In these conditions, nucleic acids bases may become essential nutrients for optimum tissue repair and function
  • Glycine, Serine, Aspartic Acid, Glutamine
orally ingested nucleic acids undergo intensive metabolic degradation in upper gi tract
Orally ingested nucleic acids undergo intensive metabolic degradation in upper GI tract
  • Over 99% of purine bases oxidized to uric acid before entering portal circulation
  • About 95% of pyrimidines are metabolized before leaving intestinal lining
  • Only 3% of ingested pyrimidines reach liver
slide31

Laser Enhancement Technology

Nutrient molecules get distorted

during food or supplementation processing. Result: reduced nutrient assimilation by the cells.

Laser Enhancement Technology reshapes nutrient molecules.

Result: increased nutrient assimilation by the cells.

extensive experimental and clinical evidence for benefit from nucleotide supplementation
Extensive experimental and clinical evidence for benefit from nucleotide supplementation
  • Increased survival in mice with Staph aureus bacteremia from 21% to 71%
  • Significantly increased survival in mice with Candida sepsis – greater effect with parenteral nucleotides than oral administration
  • Survival in animals with high dose radiation exposure increased from 5% to 50%
slide35
Single injection of RNA in mice post tumor immunization improved outcome from 0% to 40% long term survival
  • Rate of liver regeneration in rats post 70% hepatectomy significantly greater if IV nucleic acid bases given
  • In young rats with chronic diarrhea, appearance and enzyme function of intestine greatly improved
  • Improved growth and maturation in young animals
slide36
Infants given formula supplemented with nucleotides to mimic content of breast milk showed more benevolent intestinal flora an less diarrhea (50 times more nucleic acids in breast milk vs. formula which is significant in developing countries)
  • Supplemented infants had better lipid profiles with higher HDL cholesterol
  • Significant improvement in human cellular immune function
  • Significant improvement in memory in animals and humans
  • Accelerated wound healing
atp delivery specifically associated with numerous benefits
ATP delivery specifically associated with numerous benefits
  • Improved pulmonary function, even in cystic fibrosis
  • Enhanced cardiac function – strengthening the heart
  • Relief of nerve pain and improved nerve conduction
  • Direct antitumor effects (RNA nucleotide) specifically incubation with ATP breast and prostate cancer
slide38
Synergistic antitumor effects in conjunction with chemotherapy – in vitro studies suggest up to 90% dose reduction possible for certain cell types
  • IV ATP has halted progression of tumor cachexia (advanced cancer with rapid weight loss)

50 mcg/kg/minute x 24 hours x 3 weeks

  • Protection of tissues from radiation injury
  • Increased natural killer cell function
  • Survival of patients in ICU for shock (multi-organ failure) increased from 70% to 100%
slide39

Current research

Enhanced

Nucleotide

Supplementation

slide40

Reducing Homocysteine reduces the

risk of death from the top 5 killer diseases:

Heart Attack by 80%

Strokes by 82%

Cancer by 33%

Diabetes by ??%

Alzheimer\'s by 50%

slide41

Homocysteine Levels (units = micromoles/litre)

Below 6.3 = Very Low Risk

6.4 - 9.0 = Low Risk

9.1 - 15.0 = High Risk

+ 15.0 = Very High Risk

Every 5 point decrease in homocysteine level =

50% reduced risk of cardiovascular death

26% reduced risk of cancer death

methylation formula study dose response curve homocysteine level treatment group n 22
Methylation Formula Study Dose Response CurveHomocysteine Level- Treatment Group (n=22)

Active Supplementation Group Months 0-3

11

10

9.2

9

8

7.1

7

6.8

P=.00001

6.1

6

P=.00001

P=.00001

0

1

2

3

methylation formula study dose response curve homocysteine level placebo group n 11
Methylation Formula Study Dose Response CurveHomocysteine Level- Placebo Group (n=11)

9

7.9

7.9

8

7.8

P= NS

P= NS

7.3

7

P= NS

6

0 1 2 3

slide44

Methylation Formula Study Dose Response CurveHomocysteine Level- Treatment Group for subjects with Baseline Homocysteine Level > 10 (n=7)

Active Supplementation Group Months 0-3

14

13.2

12

10

9.3

8.3

P=.009

8

7.3

P=.001

P=.00001

0

1

2

3

slide45

Population study completed in Western Norway with over 18,000 subjects – Hordaland Study

Directly established a relation between homocysteine levels and chronological aging

Homocysteine level of >13 was associated with someone 65 years old

Homocysteine level of <7 was associated with someone 25 years old

slide47

Bryan Maphalala - AIDS Victim

Before taking CELLFOOD and CELLFOOD DNA-RNA CD4 Count: 10 units; Viral Load: 201,000

After taking CELLFOOD & CELLFOOD DNA-RNA for 6 months Mrs. Winnie Mandela congratulated him for his work with HIV and AIDS people

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