Practical Clinical Hematology. 4. Sickle Cell. What is Sickle cell:. Sickle cell anemia is an inherited disorder that leads to the production of an abnormal hemoglobin variant, hemoglobin S (HbS)
PowerPoint Slideshow about ' Practical Clinical Hematology' - virginia-mcknight
An Image/Link below is provided (as is) to download presentation
Download Policy: Content on the Website is provided to you AS IS for your information and personal use and may not be sold / licensed / shared on other websites without getting consent from its author.While downloading, if for some reason you are not able to download a presentation, the publisher may have deleted the file from their server.
In the RBC, variant Hbs can form polymers in low oxygen conditions, changing the shape of the RBC from a round disc to a characteristic crescent (sickle) shape.
This altered shape limits the RBC’s ability to flow smoothly throughout the body, limits the hemoglobin’s ability to transport oxygen, and decreases the RBCs lifespan from 120 days to about 10-20 days.