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GSCI 2013: Group 2-Cell and Developmental Biology

GSCI 2013: Group 2-Cell and Developmental Biology. Seth Jones, University of Kentucky  Karen Maruska, Louisiana State University Joy Davis, Baton Rouge Community College Sabrice Guerrier, Millsaps College Naila Mamoon, Millsaps College Facilitator: Peter Cavnar, University of West Florida.

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GSCI 2013: Group 2-Cell and Developmental Biology

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  1. GSCI 2013: Group 2-Cell and Developmental Biology Seth Jones, University of Kentucky  Karen Maruska, Louisiana State University Joy Davis, Baton Rouge Community College Sabrice Guerrier, Millsaps College Naila Mamoon, Millsaps College Facilitator: Peter Cavnar, University of West Florida

  2. CELLULAR RESPIRATION

  3. Context What kind of course is unit designed for? mid-level How long is unit? 1 week When will the unit be used in the course?After students have learned basic chemistry, energetics, redox rxn, protein structure, cell membrane, transport, and organelles Class size? Should be fine for all ranges

  4. Learning goal • Understand how the energy from electrons in glucose is converted to chemical energy in ATP during oxidative phosphorylation.

  5. Learning outcomes • Explain the role of oxygen in cellular respiration • Explain how the H+ gradient across the inner mitochondrial membrane is generated and how it drives ATP synthesis • Predict the effects of various drugs on oxidative phosphorylation

  6. How long can you hold your breath?

  7. Brainstorm: So why do you think we need oxygen? Loss of hydrogen atoms(becomes oxidized) ATP O2 6 CO2 6 H2O C6H12O6 6 Glucose + Heat Gain of hydrogen atoms(becomes reduced)

  8. CYTOPLASM NADH Electronscarried by NADH FADH2 NADH OxidativePhosphorylation(electron transportand chemiosmosis) Glycolysis PyruvateOxidation Citric AcidCycle Pyruvate Glucose Mitochondrion ATP ATP ATP Substrate-levelphosphorylation Substrate-levelphosphorylation Oxidativephosphorylation

  9. 1 2 Figure 6.10 H+ H+ H+ H+ H+ Mobileelectroncarriers H+ Intermem-branespace H+ Proteincomplexof electroncarriers H+ H+ ATPsynthase III IV I Inner mito-chondrialmembrane II FADH2 FAD Electronflow 2 H+ H2O O2 NAD+ NADH H+ Mito-chondrialmatrix ADP P ATP H+ Chemiosmosis Electron Transport Chain Oxidative Phosphorylation

  10. Welcome to Club Mitochondria • Instructions: Pair with a partner then identify the characters within the analogy that correspond to the following: • 1. Electrons • 2. Protons • 3. Electron transport chain (ETC) • 4. ATP synthase • 5. Mitochondrial Matrix • 6. Intermembrane space

  11. What is the layout in Club Mitochondria? Main entrance Female Patron Foyer Male Patron Dance Floor

  12. Consider a scenario where the electron transport chain ("dance line") is disrupted in the mitochondria. What is most likely to happen to the H+ concentration ([H+]) in the intermembrane space? • A. Decrease in [H+] • B. Increase in [H+] • C. No change • D. I don't know

  13. Consider a scenario where the electron transport chain ("dance line") is disrupted in the mitochondria. What change would you expect in ATP concentration in the cell? • A. Decrease in [ATP] • B. Increase in [ATP] • C. No change • D. I don't know

  14. 1 2 Figure 6.11 Inhibitors of cellular respiration Cyanide,carbon monoxide Oligomycin Rotenone H+ H+ ATPsynthase H+ H+ H+ H+ H+ DNP FADH2 FAD O2 2 H+ NAD+ NADH H+ P ADP ATP Your homework: List the signs and symptoms in victims with acute cyanide poisoning AND we would like you to extend the analogy to include oxygen and ATP H2O

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