slide1
Download
Skip this Video
Download Presentation
Renal Structure in Normoalbuminuric and Albuminuric Patients With Type 2

Loading in 2 Seconds...

play fullscreen
1 / 11

Renal Structure in Normoalbuminuric and Albuminuric Patients With Type 2 - PowerPoint PPT Presentation


  • 83 Views
  • Uploaded on

Featured Article :. Renal Structure in Normoalbuminuric and Albuminuric Patients With Type 2 Diabetes and Impaired Renal Function.

loader
I am the owner, or an agent authorized to act on behalf of the owner, of the copyrighted work described.
capcha
Download Presentation

PowerPoint Slideshow about ' Renal Structure in Normoalbuminuric and Albuminuric Patients With Type 2' - ursa


An Image/Link below is provided (as is) to download presentation

Download Policy: Content on the Website is provided to you AS IS for your information and personal use and may not be sold / licensed / shared on other websites without getting consent from its author.While downloading, if for some reason you are not able to download a presentation, the publisher may have deleted the file from their server.


- - - - - - - - - - - - - - - - - - - - - - - - - - E N D - - - - - - - - - - - - - - - - - - - - - - - - - -
Presentation Transcript
slide1

Featured Article:

Renal Structure in Normoalbuminuric

and Albuminuric Patients With Type 2

Diabetes and Impaired Renal Function

Elif I. Ekinci, P.H.D., George Jerums, M.D., Alison Skene, M.B.B.S., Paul Crammer, B.A.P.P.S.C., David Power, P.H.D., Karey Y. Cheong, B.S.C., Sianna Panagiotopoulos, P.H.D., Karen McNeil, M.B.B.S., Scott T. Baker, M.B.B.S., Paola Fioretto, M.D., Richard J. MacIsaac, P.H.D.,

Diabetes Care

Volume 36: 3620-3626

November, 2013

slide2

STUDY OBJECTIVE

  • To compare renal biopsy findings in patients with type 2 diabetes and estimated glomerular filtration rate (eGFR) and measure GFR of <60 mL/min/1.73 m2, associated with normo-, micro-, or macroalbuminuria

Ekinci E. I. et al. Diabetes Care 2013;36:3620-3626

slide3

STUDY DESIGN AND METHODS

  • In patients with normo- or microalbuminuria, renal biopsies were performed according to a research protocol
  • In patients with macroalbuminuria, biopsies were performed according to clinical indication
  • Findings were categorized according to the Fioretto classification:
  • • Category 1 (C1): normal/near normal
  • • Category 2 (C2): typical diabetic nephropathy (DN) with predominantly glomerular changes
  • • Category 3 (C3): atypical with disproportionately severe interstitial/tubular/vascular damage and with no/mild diabetic glomerular changes

Ekinci E. I. et al. Diabetes Care 2013;36:3620-3626

slide7

RESULTS

  • Typical glomerular changes (C2) of DN were observed in 22 of 23 subjects with micro- or macroalbuminuria compared with 3 of 8 subjects with normoalbuminuria
  • Predominantly interstitial or vascular changes (C3) were seen in only 1 of 23 subjects with micro- or macroalbuminuria compared with 3 of 8 normoalbuminuric subjects
  • Mesangial area increased progressively from normal controls to patients with type 2 diabetes and normo-, micro-, and macroalbuminuria
  • Varying degrees of arteriosclerosis were seen in seven of eight subjects with normoalbuminuria

Ekinci E. I. et al. Diabetes Care 2013;36:3620-3626

slide10

CONCLUSIONS

  • Typical renal structural changes of DN were observed in patients with type 2 diabetes and elevated albuminuria
  • In normoalbuminuric renal insufficiency, these changes were seen less frequently, likely reflecting greater contributions from aging, hypertension, and arteriosclerosis

Ekinci E. I. et al. Diabetes Care 2013;36:3620-3626

ad