Sponsored Links
This presentation is the property of its rightful owner.
1 / 51

MuDanJiang Medical College The department of pathophysiology PowerPoint PPT Presentation


  • 87 Views
  • Uploaded on
  • Presentation posted in: General

发热. fever. MuDanJiang Medical College The department of pathophysiology. 2005.3. Preoptic anterior hypothalamus,POAH. 正常体温调节基本机制示意图. POAH. 调定点 (Set Point,SP). 深部温度感受器. 外周温度感受器. 骨骼肌. 外周血管. 产热. 汗腺. 散热. 平衡. (蒸发、辐射、对流、传导). 第 1 节 概述

Download Presentation

MuDanJiang Medical College The department of pathophysiology

An Image/Link below is provided (as is) to download presentation

Download Policy: Content on the Website is provided to you AS IS for your information and personal use and may not be sold / licensed / shared on other websites without getting consent from its author.While downloading, if for some reason you are not able to download a presentation, the publisher may have deleted the file from their server.


- - - - - - - - - - - - - - - - - - - - - - - - - - E N D - - - - - - - - - - - - - - - - - - - - - - - - - -

Presentation Transcript


fever

MuDanJiang Medical College

The department of pathophysiology

2005.3


Preoptic anterior hypothalamus,POAH

POAH

(Set Point,SP)


1

fever0.50C

380C

38.10C~390C

39.10C~410C

>410C


  • (hyperthermia):



---

----


2

Etiology and pathogenesis

.(pyrogenic activators)EPEP

Ep

exogenous pyrogen


exogenous pyrogen

G+

1 G

---(LPS)

bacteria

lipopolysaccharide

2 VV

virus

3 ----


endotoxin, ET1600C2h

ET ETEP EP


4 ----

------

1

2 Ep

3.

4.


.

endogenous pyrogen,EP

EP


EP

  • Beesonleukocyte pyrogen , LP

  • Atkin endogenous pyrogen,EP

  • EPEPLP



1 --1 interleukin-1 IL-1

17kD

IL-1IL-1

700C 30min


2. tumor necrosis factor TNF

  • TNF-TNF-

  • 700C 30min


3. interferon IFN

  • IFNIFN


4.-6 interleukin-6 IL-6

  • 18421kD

  • LPSIL-1TNF


-1 macrophage inflammatory protein-1MIP-1

5.

(ciliary neurotrophic factor)

-8(interleukin-8, IL-8)

(endothelin)


3


LPS

LPSLBP

CD14

LPS--sCD14

EP


LPS--LBP--mCD14

LPS

Toll-like receptors , TLR

(NF-kB)


LBP

LPS

?

CD14

TLR4

?

?

NF-B pathway

MAPK pathways

TNF-IL-1IL-6etc

LPSEPEP

Cellular membrane


POAH

MAN VSA

  • EP

  • EP

  • EP


M

M

POAH

POAH

.OVLT

OVLT

EP


EP


1.

1E(prostaglandin E,PGE)

PGE

EP PGE

EP+ PGE

PGE, PGE

EP


Na+/Ca2+

0.9%NaCl

Ca2+

EGTA cAMP

CaCl2 EGTA

cAMP

EP Na+/Ca2+ cAMP

cAMP


cAMP

cAMP


AMP cAMP 5AMP

PDE--theophiline)

cAMPEP

PDE--(nicotinic acid)

cAMP

EP

.EPPGE

cAMP

cAMPEP


(4)CRH

CRH

IL-1IL-6CRH

CRHCRH CRH

CRH-R

IL-1IL-6EP

TNFIL-1CRH


5nitric oxide,NO

POAHOVLT


2.

1AVP

9 .


  • 2MSH

  • MSH

  • EPMSH

  • MSH

  • MSH

  • 31(lipocortin-1)

  • GC-1

  • -1IL-1IL-6IL-8CRH


()

EPEP

EPPOAHOVLT


.Development of Fever

  • (The fervescence period)

  • (The persistent febrile period)

  • (The defervescence period)


>

=

>


42 C

37C

3


3 Alterations in Metabolism and Function

  • . (Metabolic alterations )

  • .

  • 1 .


2 .

3 .


4 .

Na+Cl-

Na+Cl-


. ( Functional alterations)

1 . Central nervous system

IL-1

------ 6~6CNS


2.Circulrtory system

HR* HR CO

+ MVO2

HR

Bp HR Bp

Bp


3 .Respiratory system

CO2

4 . Digestive system


  • .

  • 1 .

  • Fe

  • 2 .

    IL-1TNFIFN


    3.acute phase response


    4 Principles of Treaments

    • Treament of primary affections

    • General treament to fever

    • 40


    • 40

    • Antifebrile Treament

    • EP

    • AVP-MSH


    :,,,;

    ;

    EP,;

    :(,,)

    ;

    :.


    Case

    23

    30.5h

    PET41.4CP116/R24/BP13.3/8kPa

    ++116/

    WBC17.4109/L4~10 109/L2%16%2%80%CO2CP17.94

    mmol/L23~31mmol/L)

    1

    h38.4 C4


    Question?

    1.

    2.

    3.

    4.


  • Login