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Franco Valenza Department of Pathophysiology and Transplantation

New perspectives in ECMO 2012 ECMO and lung transplant program. Franco Valenza Department of Pathophysiology and Transplantation Fondazione IRCCS Ca' Granda - Ospedale Maggiore Policlinico. New perspectives in ECMO 2012 ECMO and lung transplant program. No conflict of interest.

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Franco Valenza Department of Pathophysiology and Transplantation

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  1. New perspectives in ECMO 2012 ECMO and lung transplant program Franco Valenza Department of Pathophysiology and Transplantation Fondazione IRCCS Ca' Granda - Ospedale Maggiore Policlinico

  2. New perspectives in ECMO 2012 ECMO and lung transplant program No conflict of interest

  3. New perspectives in ECMO 2012 ECMO and lung transplant program Conventional Un-conventional

  4. Conventional ECMO - PGD ECMO - Support ECMO - Bridge

  5. Lung Transplantation before during after ECMO - PGD ECMO - Support ECMO - Bridge

  6. Anticoagulation Hemodynamics Hypoxia - Hypercapnia ECMO - PGD ECMO - Support ECMO - Bridge

  7. Wen-Je, Artifical Organs (2001); 25(8):607

  8. Bittner, Eur J Cardio Thor Surg (2007); 31: 462

  9. Burdett, Inter CardioVasc Thor Surg (2012);15:432

  10. Ca’ Granda, from 3/2011 to present

  11. ECMO - PGD ECMO - Support ECMO - Bridge

  12. ECMO Bridge Lung Transplantation Pub Medsearch Lang, Transplantation (2012);93:729 Bittner, Ann Thor Surg (2012);94:942

  13. ECMO Bridge Lung Transplantation Pub Medsearch Awake vs.Intubated Ambulatory ECMO bridge Early vs. Late

  14. ECMO - PGD ECMO - Support ECMO - Bridge

  15. Postoperative “treatment” tool Oto, Ann Thor Surg (2004);78:1230

  16. Intraoperative “prevention” tool Low perfusion pressure Bhabra, Ann Thor Surg 1996;61:1631 Bhabra, Ann Thor Surg 1998;65:187 Pierre, J Thorac Cardiovasc Surg 1998;116:932 Clark, J Thorac Cardiovasc Surg 1998;115:1335 Halldorsson, J Thorac Cardiovasc Surg 1998;115:415 Protective ventilation De Perrot, J Thorac Cardiovasc Surg 2002;124:1137 Crimi, Am J respir Crit Care Med 2005;174:178 Chiang, Resuscitation 2008;79:147 Valenza, Organ Tissue & Cells (2012)

  17. McILwain, Lab Invest (2010);90:128

  18. MCP-1 CXCL-10 * Control BD Ischemia Graft Relative expression IL-8 HMGB-1 * * * Control BD Ischemia Graft Control BD Ischemia Graft Control BD Ischemia Graft Valenza, un published

  19. Valenza, un published

  20. New perspectives in ECMO 2012 ECMO and lung transplant program Conventional Un-conventional

  21. ECMO - PGD ECMO - Support ECMO - Bridge RECIPIENT

  22. LUNG DONOR reverse - ECMO ECMO - PGD ECMO - Support ECMO - Bridge RECIPIENT

  23. reverse - ECMO Ex-Vivo Lung Perfusion (EVLP)

  24. Cypel, NEJM (2011);364:1431

  25. * Valenza, Transpl Proc (2012); 44:1826-9

  26. LUNG DONOR donor - ECMO reverse - ECMO ECMO - PGD ECMO - Support ECMO - Bridge RECIPIENT

  27. Maastricht VI Refractory cardiogenic shock ECMO Liver OLTX LUNG DONOR BRAIN DEATH CARDIAC DEATH Rat Lungs Maastricht III Lung Harvest Maastricht II EVLP ECMO Transplantation

  28. …. in conclusion No way I’m gonna stay with-out ECMO! Bridge Support PGD RECIPIENT EVLP DCD LUNG DONOR

  29. …. thanks for your attention!

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