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* Environment=Genetic susceptibility to

Unified Theory of Diabetes and All Its Complications. Most Mechanisms of B-Cell Damage (Hyperglycemia) Overlap with Causes of Vascular Disease : Provides Logic for Treatment Regimes and CV Benefits of DM Meds. * Environment=Genetic susceptibility to

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* Environment=Genetic susceptibility to

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  1. Unified Theory of Diabetes and All Its Complications Most Mechanisms of B-Cell Damage (Hyperglycemia) Overlap with Causes of Vascular Disease : Provides Logic for Treatment Regimesand CV Benefits of DM Meds *Environment=Genetic susceptibility to eg: poor diet,lack of exercise, sleep disorders,, food AGEs, Gut Biome **Insulin Resistance= Centrally Induced, Peripheral, Stress Hormones, Gut Biome MacroVascular Damage Inflammation Immune Reg. Polygenic monogenic epigenetic Environment Brownlee’s Unified Theory of Complications Insulin Resistance-Part of Cardiometabolic Syndrome with BP, Lipid MicroVascular Damage *Environment=Genetic suceptibility to eg: viruses, endocrine disruptors, food AGEs, Gut Biome; **Insulin Resistance= Centrally Induced, Peripheral, Stress Hormones, Gut Biome

  2. Unified Theory of Diabetes and All Its Complications Most Mechanisms of B-Cell Damage (Hyperglycemia) Overlap with Causes of Vascular Disease : Provides Logic for Treatment Regimesand CV Benefits of DM Meds All Complications Biome G e N e S In C O Mm O n Inflam Immune Reg. Ins Res.-Part of Cardiometabolic Syndrome with BP, Lipid Environment Brownlee’s Unified Theory of Complications epigenetic Polygenic monogenic Epigenetics- via ROS/ miRNAs Ins Res.-Part of Cardiometabolic Syndrome *Environment=Genetic suceptibility to eg: viruses, endocrine disruptors, food AGEs, Gut Biome; **Insulin Resistance= Centrally Induced, Peripheral, Stress Hormones, Gut Biome

  3. Unified Theory of Diabetes and All Its Complications Most Mechanisms of B-Cell Damage (Hyperglycemia) Overlap with Causes of Vascular Disease : Provides Logic for Treatment Regimesand CV Benefits of DM Meds *Environment=Genetic susceptibility to eg: poor diet,lack of exercise, sleep disorders,, food AGEs, Gut Biome **Insulin Resistance= Centrally Induced, Peripheral, Stress Hormones, Gut Biome MacroVascular Damage Inflammation Immune Reg. Polygenic monogenic epigenetic Environment Brownlee’s Unified Theory of Complications Insulin Resistance-Part of Cardiometabolic Syndrome with BP, Lipid MicroVascular Damage *Environment=Genetic suceptibility to eg: viruses, endocrine disruptors, food AGEs, Gut Biome; **Insulin Resistance= Centrally Induced, Peripheral, Stress Hormones, Gut Biome

  4. Unified Theory of Diabetes and All Its Complications Most Mechanisms of B-Cell Damage (Hyperglycemia) Overlap with Causes of Vascular Disease : Provides Logic for Treatment Regimesand CV Benefits of DM Meds *Environment=Genetic susceptibility to eg: poor diet,lack of exercise, sleep disorders,, food AGEs, Gut Biome **Insulin Resistance= Centrally Induced, Peripheral, Stress Hormones, Gut Biome ALL COMPLICATIONS [Micro-MacroVascular Damage] Inflammation Immune Reg. Polygenic monogenic epigenetic Environment Brownlee’s Unified Theory of Complications Insulin Resistance-Part of Cardiometabolic Syndrome with BP, Lipid *Environment=Genetic suceptibility to eg: viruses, endocrine disruptors, food AGEs, Gut Biome; **Insulin Resistance= Centrally Induced, Peripheral, Stress Hormones, Gut Biome

  5. Unified Pathophysiologic Basis of Diabetes and Its Complications: Implications for Understanding and Evaluating Risk, Diagnosis , Therapy

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