Aging of the Nervous System: Functional Changes. P.S. Timiras. Acetic acid. Choline. AChE inhibitor. Acetylcholinesterase Inhibition. Presynaptic nerve terminal. Muscarinic receptor. Postsynaptic nerve terminal. Nicotinic receptor. Acetylcholine (ACh). Acetylcholinesterase (AChE).
Aging of the Nervous System:Functional Changes
Presynaptic nerve terminal
Postsynaptic nerve terminal
Nordberg A, Svensson A-L. Drug Safety. 1998;19:465-480.
Major functional deficits/ pathologies involve:
Motility (e.g. Parkinson’s Disease)
Senses and communication
Cognition (e.g. dementias)
Affect and mood (e.g. depression)
Blood circulation (stroke, multi-infarct dementia)
Parkinson’s Disease: Chapter 8, pp. 110-113
Dementias: Chapter 8, pp. 130-136
Bones and Joints
Central Nervous System
Dementia (from the Latin de-mens, without mind) is a clinical syndrome that refers to a global deterioration of intellectual and cognitive functions characterized by a defect of all five major mental functions:
But with persistence of a
From Table few. However impaired function and increased pathology do occur.
Learning at all Ages Induces Successful Aging few. However impaired function and increased pathology do occur.