Photo acoustic spectroscopy of beta amyloids - research overview
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Photo acoustic spectroscopy of beta amyloids - research overview. Group Meeting February 08. First setup. goal –generating and characterization of pa signal Wavelength – 1550 nm. 1 . OTDR. OTDR pulse width: 100ns-1 μ s. PZT. fiber splitter. Erbium Amplifier. 90%. 10%.

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First setup overview

goal –generating and characterization of pa signal

Wavelength – 1550 nm

1. OTDR

OTDRpulse width: 100ns-1μs

PZT

fibersplitter

Erbium Amplifier

90%

10%

24V+ Voltage source

RF Amplifier

detector

reference

Photo-acoustic signal

Scope


2. Tunable Laser overview

Wavelength 1535 -1565 nm

Polarization controller

TunableLaser

Function Generator

Modulator

Erbium Amplifier x2

PZT

95%

fibersplitter

5%

24V+ Voltage source

RF Amplifier x3

Reference

Signal

detector

Scope


~5 overviewmicro second

PZT

~5 micro second


Water: overview

Abs coefficient =11.6 cm^-1

heat capacity = 4.184J cm-3 K-1 

Thermal expansion =20710-6/K

ethanol:

Abs coefficient =5.7 cm^-1

heat capacity = 1.925Jcm-3 K-1

Thermal expansion =75010-6/K



1550 change of glucose concentration

Spectrum

200

300

800

2,000

10,000

nm

UV

visible

Near-IR

IR

peptidic bond(190-250 nm)

Over tones (1000-2600)

starching vibration of aromatic residues(3.3,6.25,6.6 μm)

aromatic residues(~280nm)

starching vibration of amide bond (5.88-6.25 μm )

bending vibration of aromatic residues (11.1-14.5 μm)


Technion experiment change of glucose concentration :

Nd:YAG fourth harmonic 266nmlaser:

1.Insulin


2.lysosin change of glucose concentration

3.Beta amyloid


opo experiment: change of glucose concentration

OPO -optical parametric oscillator


1. insulin change of glucose concentration

Wavelength ~1660nm

Zoom in on first peak

2. water


Goals for the short future change of glucose concentration

  • improving the sensitivity of the measurements

  • Defining the concentration and absorption coefficient of solutions by pa measurement

  • Finding the amyloids over tones spectra , and characterize its pa signal

  • Examine the ability of performing pa measurements in the MIR

  • Completing the simulation of the pa signal


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