alumina fibers in orthopedics implant osteoblast adhesion application
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ALUMINA FIBERS IN ORTHOPEDICS IMPLANT: Osteoblast Adhesion Application. Dr.Hasmaliza Mohamad Ruzainah Abdullah School of Materials and Mineral Resources Engineering, Universiti Sains Malaysia, 14300 Nibong Tebal, Pulau Pinang, Malaysia. Alumina (Al 2 O 3 ) .

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alumina fibers in orthopedics implant osteoblast adhesion application

ALUMINA FIBERS IN ORTHOPEDICS IMPLANT: Osteoblast Adhesion Application

Dr.Hasmaliza Mohamad

Ruzainah Abdullah

School of Materials and Mineral Resources Engineering,

Universiti Sains Malaysia,

14300 Nibong Tebal,

Pulau Pinang, Malaysia

slide2

Alumina (Al2O3)

Alumina is an important engineering material for high temperature industries.

Properties :

  • High strength and modulus.
  • Resistance to attack by molten metals and non-oxide materials.
  • Chemical inertness in both oxidizing and reducing atmosphere.
  • Low thermal conductivity and good electrical insulation
biomedical application of al 2 o 3
Biomedical application of Al2O3
  • Dental Implant
  • Bone implant
    • Joint replacement: Knee prostheses, ankle
    • joint, shoulders and fingers.
    • Implant adhesion: Osteoblast adhesion
objectives
Objectives
  • To increase the activities of bone cells on the surface of material used in the design of orthopedic implants.
  • Enhanced functions of osteoblasts
slide5

Previous study:

  • Frequently, problems with orthopaedic implants occur owing to either loosening of the implant, osseo-degradation of bone surrounding the implant or hypersensitivity of the patient to the particular metal
  • Hydroxyapatite-coated implants have been successful for the most part. It has been found that bone apposition on the surface of porous hydroxyapatite-coated implants is better than that on metallic porous coatings
slide6

Previous study: (cont..)

  • However, numerous problems are still encountered with these approaches. For example, the average lifetime of hydroxyapatite-coated implants needs improvement, owing to high solubility rates that can lead to degradation of the coating and loosening at the bone-hydroxyapatite interface
slide7

Present study:

  • Alumina fibers will use to increase the coating toughness
  • Electrospinning provides opportunities to manipulate and control surface area, fiber diameter, porosity and pore size of nanofiber matrices
  • Study the effect of various properties of alumina fibers on adhesion
slide8

Synthesis of the alumina fiber

  • sol – gel  Electrospinning  press  sinter
    • The combination of sol-gel processing with electrospinning techniques will provides a versatile technique for producing ceramics nanofibers
slide11

The aim of nanoscale alumina in osteoblast adhesion

  • Nanofiber alumina (less than 100 nm in diameter) more closely simulates the physical geometry of hydroxyapatite crystals and collagen fibers in bone that osteoblasts are accustomed to interact to.
advantages of alumina fibers in osteoblast adhesion
Advantages of alumina fibers in osteoblast adhesion:
  • Increase the toughness of HAp coating
  • Give good adhesion to implant
  • Increase the degradation rate of HAp coating
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