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Principles of Immunology Introduction/ Historical Perspectives 1/17/06

Principles of Immunology Introduction/ Historical Perspectives 1/17/06. “Everybody can be great, because everybody can serve.” Martin Luther King, Jr. The immune system includes the tissues, cells and molecules involved in immunity, both innate and adaptive. Written exercise.

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Principles of Immunology Introduction/ Historical Perspectives 1/17/06

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  1. Principles of ImmunologyIntroduction/Historical Perspectives1/17/06 “Everybody can be great, because everybody can serve.” Martin Luther King, Jr. The immune system includes the tissues, cells and molecules involved in immunity, both innate and adaptive. Written exercise

  2. Historical Events in Immunology • 1796-Edward Jenner (smallpox) • 1881-Loius Pasteur (vaccines) • 1884-Elie Metchnikoff (phagocytes) • 1890-Emil von Behring* (antibodies) • 1895-Jules Bordet* (complement) • 1906-August Wasserman (syphilis)

  3. Historical Events in Immunology(cont’d) • 1959-Rodney Porter Gerald Edelman* (antibodies) • 1960-F McFarlane Burnet* (tolerance) • 1975-Cesar Milstein*(monoclonal Ab) • 1987-Susumu Tonegawa* (genetics) • 1996-Peter Doherty Rolf Zinkernagel* (MHC)

  4. Sub disciplines of Immunology • Immunobiology • Immunochemistry • Immunopathology • Immunogenetics • Immunodiagnostics • Immunotherapy

  5. Overview of the Immune System • Innate immunity • Pre-existing • Non-specific • Adaptive immunity • Responsive • Specific

  6. Cells of the Immune System • Phagocytic cells • Nonspecific • Specific • Lymphocytes • B lymphocytes • T lymphocytes • T helper • T cytotoxic

  7. Two Arms of the Adaptive Immune System • Humoral immunity • Antibodies • Cell-mediated immunity • T-cells

  8. Immunological Memory • More rapid • More intense • More prolonged

  9. Chemical Mediators • Extracellualar • Cytokines • Complement • Intracellular

  10. Antigens and Antibodies • Antigens • Chemical makeup • Types of antigens • Antibodies • Chemical makeup • Roles • Functions

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