Acetylcholinesterase 1
Download
1 / 12

Acetylcholinesterase 1 - PowerPoint PPT Presentation


  • 531 Views
  • Uploaded on

Acetylcholinesterase (1). Sites of location Cholinergic neurons Cholinergic synapses Neuromuscular junction Red blood cells Substrates Acetylcholine is the best substrate Methacholine is a substrate

loader
I am the owner, or an agent authorized to act on behalf of the owner, of the copyrighted work described.
capcha
Download Presentation

PowerPoint Slideshow about 'Acetylcholinesterase 1' - talmai


An Image/Link below is provided (as is) to download presentation

Download Policy: Content on the Website is provided to you AS IS for your information and personal use and may not be sold / licensed / shared on other websites without getting consent from its author.While downloading, if for some reason you are not able to download a presentation, the publisher may have deleted the file from their server.


- - - - - - - - - - - - - - - - - - - - - - - - - - E N D - - - - - - - - - - - - - - - - - - - - - - - - - -
Presentation Transcript
Acetylcholinesterase 1 l.jpg
Acetylcholinesterase (1)

Sites of location

Cholinergic neurons

Cholinergic synapses

Neuromuscular junction

Red blood cells

Substrates

Acetylcholine is the best substrate

Methacholine is a substrate

Hydrolyzes ACh at greater velocity than choline esters with acyl groups larger than acetate or proprionate


Acetylcholinesterase 2 l.jpg
Acetylcholinesterase (2)

Esters that are not substrates

Bethanechol

Carbachol

Succinylcholine

Its inhibition produces synergistic interaction with methacholine and additive actions with bethanechol and carbachol

Drugs that block its hydrolysis of esters are called cholinesterase inhibitors


Slide3 l.jpg
Drug Interactions of Choline Esters and Inhibitors of Acetylcholinesterase - SynergismversusAdditivity

Methacholine

Carbachol

Bethanechol


Butyrylcholinesterase l.jpg
Butyrylcholinesterase Acetylcholinesterase - Synergism

(Plasma esterase, pseudocholinesterase, serum esterase, BuChE, PseudoChE)


Butyrylcholinesterase 1 l.jpg
Butyrylcholinesterase (1) Acetylcholinesterase - Synergism

Sites of location

Plasma, liver, glial cells, other tissues

Substrates

Butyrylcholine is the best

Acetylcholine

Succinylcholine

Procaine


Butyrylcholinesterase 2 l.jpg
Butyrylcholinesterase (2) Acetylcholinesterase - Synergism

Esters that are not substrates

Methacholine, bethanechol, and carbachol

Is inhibited by carbamyl and organophosphate inhibitors of acetylcholinesterase


Active site of acetylcholinesterase l.jpg
Active Site of Acetylcholinesterase Acetylcholinesterase - Synergism


Interaction of ache and acetylcholine l.jpg
Interaction of AChE and Acetylcholine Acetylcholinesterase - Synergism


Acetylation of ache and release of choline l.jpg
Acetylation of AChE and Release of Choline Acetylcholinesterase - Synergism



Carbamyl inhibitors of ache l.jpg
Carbamyl Inhibitors of AChE Acetylated-AChE to Liberate AChE


ad