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Acetylcholinesterase (AChE). Natalie, Kristin. Protein Synthesis. http://mx.nthu.edu.tw/~ cychuang/files/cell1.jpg. Protein Structures. http://biochemchronicles.files.wordpress.com/2013/04/image7.jpg. http://edtech2.boisestate.edu/millerc/edtech573/biochem_images/lockkey.gif. AChE.

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protein synthesis
Protein Synthesis

http://mx.nthu.edu.tw/~cychuang/files/cell1.jpg

protein structures
Protein Structures

http://biochemchronicles.files.wordpress.com/2013/04/image7.jpg

slide4

http://edtech2.boisestate.edu/millerc/edtech573/biochem_images/lockkey.gifhttp://edtech2.boisestate.edu/millerc/edtech573/biochem_images/lockkey.gif

slide5
AChE

http://pubs.acs.org/doi/abs/10.1021/cr00081a005

Breaks down acetylcholine, a neurotransmitter, into their ions which then allow many unconscious bodily functions to be performed

AChE catalyzes the reactions that are found where the nerves and muscles meet (neuromuscular junctions ) and in the brain

structure
Structure
  •  Joel L. Sussman unveiled the structure in 1991 using X-rays
  • 537 amino acids long
  • Active site deep inside enzyme
    • Has two parts the anionic site and the esteratic site

http://www.sciencemag.org/content/253/5022/872

http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2142791/pdf/8003956.pdf page 1

hydrolysis of acetylcholine ach
Hydrolysis of acetylcholine (ACh)
  • Once broken down into acetate and choline, those ions are then transmitted and functions can be performed, i.e. digestion, muscle movement, decision making, sexual arousal, salivation, and urination.
  • 25000 per second

http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2142791/pdf/8003956.pdf page 1

http://users.rcn.com/jkimball.ma.ultranet/BiologyPages/E/Enzymes.html

alzheimer s disease
Alzheimer’s occurs when concentration of ACh drop up to 90 %

Drugs are made to help lessen the effects of Alzheimer’s by inhibiting AChE

This allows for the concentration of ACh to increase slightly

Alzheimer’s Disease

http://web.williams.edu/imput/synapse/pages/IA5.html

slide9
AChE needs it’s specific shape that it gets from the DNA and RNA that code from it
  • Without that specific shape, the substrate, ACh, wouldn’t bond and wouldn’t have a way to be catalyzed which would make many vital functions in the human body stop

http://www.rcsb.org/pdb/101/motm.do?momID=54

video
Video
  • http://www.youtube.com/watch?v=7MSDS6jKJSA
quiz time
Quiz Time!
  • What does AChE do?
  • Where is it located?
  • How many substrates are catalyzed per second?
  • How amino acids does AChE have?