Milk intolerance in infants. Food intolerance or food allergy ? Intolerance is not immune mediated For cow’s milk = lactose intolerant Lactose intolerance in infants = enteropathy Allergy is immune mediated IgE-mediated - local or systemic Non-IgE-mediated - local or systemic.
David Hill et al
N = 4
Hill et al, J Pediatr 1999
'chronic indigestion met with in persons of all ages,
Yet especially apt to affect children between 1 and 5 years old‘
Lecture at GOS, 5th October, 1887
Dicke WK (1950) Coeliakie. MD Thesis, Utrecht.
Farrell and Kelly,
Crohn BB, Ginzburg L, Oppenheimer GD. Regional ileitis: A pathologic and clinical entity.J Am Med Assoc 1932; 99: 1323 – 1328.
Highly effective first-line therapy
Polymeric formulas more palatable
Reduce pro-inflammatory cytokines
Increase regulatory cytokines
Animal models suggest alteration of gut flora
Motivation of child and family critical