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Fructose Intolerance

Glycogen. Fructose Intolerance. Fructose. Lack of Pi Allosteric Inhibition by F-1-P. ATP. Glucose-6-P. Glucose. ADP. Fructose-1-P. 1 o Deficiency: F-1-P Aldolase. F-1,6-BP. Effects: F-1-P Pi Glycogenolysis Gluconeogenesis Blood Glucose

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Fructose Intolerance

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  1. Glycogen Fructose Intolerance Fructose • Lack of Pi • Allosteric Inhibition by F-1-P ATP Glucose-6-P Glucose ADP Fructose-1-P 1o Deficiency: F-1-P Aldolase F-1,6-BP • Effects: • F-1-P • Pi • Glycogenolysis • Gluconeogenesis • Blood Glucose • Reducing sugar ( ) in urine DHAP + Glyceraldehyde DHAP G-3-P Pyruvate • Treatment: • Limit Fructose/Sucrose

  2. Myocardial Infarction Glycogen • 1o Problem- Lack of O2 • Block of aerobic metabolism (ETS) • Induction of anaerobic metabolism (Glycolysis) • Effects: • ATP • Creatine Phosphate • Glycogen • LDH • Lactate/Pyruvate • NADH/NAD GLYCOLYSIS Lactate Dehydrogenase (LDH) Glucose NADH Pyruvate Lactate NAD Acetyl CoA TCA CYCLE ETS O2 NADH FADH2 ATP H2O ADP + Pi CO2

  3. Alcohol Abuse Ethanol Acetaldehyde Acetate NADH NAD NADH NAD NADH/NAD • Effects: • NAD requiring reactions/ NADH forming reactions • Lactate/Pyruvate • Gluconeogenesis • Fatty Acid Oxidation • Glycerol-3-P • Blood Glucose • NAD to NADH Reactions: • G-3-P to 1,3 BPG (Glycolysis) • Lactate to Pyruvate (Glycolysis) • Glycerol-3-P to DHAP (Branch of Glycolysis) • Many others

  4. Glycogen Storage Disease (Type 1)Von Gierke’s Disease Glucose-6-P Phosphatase Glycogen Glucose Glucose-6-P Pi • Effects: • Glycogen • Blood Glucose • Free fatty acids • Triglycerides • Cholesterol • Uric Acid • Lactate • Low Glucose: • Glucagon • Phosphorylase Activity • Glycogen to Glucose-6-P

  5. Glucose-6-P Dehydrogenase Glucose-6-P Dehydrogenase 6-Phosphogluconate DH CO2 6-P-Gluconate Ribulose-5-P Glucose-6-P NADPH NADPH NADP NADP NADPH/NADP • Effects: • NADPH levels • Reducing Power • GSH/GS-SG • Free radical/Peroxides • Hemoglogin • Hemolytic Anemia • Lens

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