Substrate

1. Color the “Substrate” pieces red, Color the “Enzyme” pieces blue, Color the “Product” yellow • Color the “Denatured Enzyme” green • Title the paper LOCK AND KEY HYPOTHESIS (be as creative as you like). • Cut out the “substrate”, “enzyme”, and “product”. • Place a substrate molecule on the far left of the paper (orientate so that it will fit with enzyme). • Write a + symbol next to the substrate. Place an enzyme next to the + symbol. • Label lock and key under the appropriate pictures. • Draw an arrow pointing to the enzyme area that the substrate will fit into. Label it the active site. • Draw an arrow to the right of the enzyme. • Take a second pair of enzyme/substrate cut-outs; arrange them fitting snugly together • in the same orientation to the right of the arrow. • Label this pair the Enzyme Substrate Complex. Draw an arrow to the right of the complex. • Position the product leaving the third enzyme. • Label the enzyme as reusable and draw an arrow back to the beginning. • Place the “Denatured Enzyme” at the lower left hand corner. • Place the Substrate above the active site of the denatured enzyme . • Show the teacher your work and then you can glue them on the paper. Substrate Substrate Product Enzyme Enzyme Enzyme Denatured Enzyme Substrate Substrate Substrate Substrate