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Mechanics of ventilation

Mechanics of ventilation. How the lung is supported and moved. Pneumothorax of right lung. ribs. Rotation axis. insp. exsp. Air flow. Static recoil. Interpleural pressure. Tidal volume. Interpleural pressure. ↓ C L. P = P. P=T/r. ↓T. ↑r.

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Mechanics of ventilation

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  1. Mechanics of ventilation How the lung is supported and moved

  2. Pneumothorax of right lung

  3. ribs Rotation axis

  4. insp exsp Air flow Static recoil Interpleural pressure Tidal volume Interpleural pressure

  5. ↓CL P = P P=T/r ↓T ↑r Dipalmitol fosfatidil cholin + protein

  6. Alveoli are larger at the apex (upper panel) than base (lower)

  7. ∆V C = ∆V / ∆P ∆P

  8. ∆P . R=∆P / ∆V . ∆V

  9. Number of airways increases rapidly with generation

  10. Mechanism of dynamic compression

  11. Work done on the lung during breathing

  12. Transport of gas from alveoli to blood

  13. 0.5 μm Gas Membrane blood

  14. Very thin blood-gas barrier

  15. Limitation by perfusion Limitation by diffusion

  16. Respiration at the limit: surviving on the summit of Mt Everest

  17. Highest altitudes attained in the last century

  18. Maximum oxygen uptake at increasing altitudes

  19. Climbers Ranked by their Hypoxic Ventilatory Response

  20. Alveolar Pco2 at Extreme Altitudes

  21. Pulmonary Gas Exchange on the Everest Summit

  22. O2 Dissociation Curves in High-Altitude Mammals

  23. Decrease of barometric pressure with altitude

  24. Climber on the Everest Summit

  25. Polycythemia at 4600 m altitude Hemoglobin concentration 19.8 g/dl Arterial PO2 45 mm Hg O2 saturation 81% O2 concentration 22.4 ml/dl

  26. DLO2 = VO2 / PAO2 Pc O2 DLCO = VCO / PACO Time of blood flow through pulmonary capillary

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