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CReST Program Update

CReST Program Update. The Story…. “One in a billion” – genomic medicine discovers the cause of a young boy’s disease Howard Jacobs, PhD Human Molecular Genetics Center, Medical College of Wisconsin X-linked Inhibitor of Apoptosis (XIAP) Cysteine -aspartic acid proteases ( caspases )

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CReST Program Update

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  1. CReST Program Update

  2. The Story… “One in a billion” – genomic medicine discovers the cause of a young boy’s disease • Howard Jacobs, PhDHuman Molecular Genetics Center, Medical College of Wisconsin • X-linked Inhibitor of Apoptosis (XIAP) • Cysteine-aspartic acid proteases (caspases) • XIAP and initiator caspase 9 • biochemistry: structure and protein interactions • genetics: effect of mutations in XIAP

  3. How students approach the story… Fall semester: integrated into two courses • Biochemistry (Heather Mernitz) • Previous CReST student introduced XIAP/caspase • Model system for core concepts • Capstone project: Student teams investigated one of three pathways in detail • Genetics (Carl Ball) • Genomics of “One in a Billion” • Capstone project: One student team investigated an genetic disorder in XIAP gene • Capstone: Public joint poster session

  4. How students approach the story… Spring semester: independent study • Tina Jesulin, Sara Klosiewski, Phaya Lem, Jessica Weiss Build on foundation from course work • Goal: model illustrating XIAP function • Biochemical principles • Genetic variants • Research XIAP literature • Selected problem – see their poster

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