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Clinical Research Sample Terminology (CReST) Affinity Group Update

Clinical Research Sample Terminology (CReST) Affinity Group Update. Davera Gabriel, UC Davis Kristi Eckerson, Emory University. CReST Goals. Initial work to focus on human biospecimens Animal, microbial & environmental in future Development use cases & requirements

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Clinical Research Sample Terminology (CReST) Affinity Group Update

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  1. Clinical Research Sample Terminology (CReST) Affinity Group Update Davera Gabriel, UC Davis Kristi Eckerson, Emory University

  2. CReST Goals • Initial work to focus on human biospecimens • Animal, microbial & environmental in future • Development use cases & requirements • supports data-sharing, research repositories • Development of standards-based, common semantics • Common domain model • Terminology model • Development of sample content for use by CTSA IKFC organizations • Value Sets

  3. CReST Process & Approach • Review relevant reference content • data standards, terminologies, coding systems… • Review current implementations to develop requirements, use cases • Include biobanking • Validate model & value set content through use by CTSA orgs

  4. CReST progress to-date • Use case development • Validating at member organizations • Domain model review • Limit to samples • Add biobanking attributes • Value set development • Established standards • Implemented systems

  5. CReST ‘Atomic’ Use Cases • Samples obtained, measured, discarded • Results recorded • Samples obtained, measured, banked • + storage information • Samples obtained, alloquots created, tracked in multiple locations • + multiple results, locations

  6. Gender / Sex Species Units of Measure Blood Type Race Ethnicity Anatomic Location Sample Types Sample Container Collection Method Sample Additives Sample Source Test Codes Out of scope: Antigen expression (outside of blood type) Transplant requirements Cell line Microbial domain CReST Value Sets

  7. CReST Participants • Jonas Almeida, UAB • Mathias Brochhausen, UAMS • Kristi Eckerson, Emory • Helena Ellis, Duke • Davera Gabriel, UC Davis • Carol Hill, Duke • Aenoch Lynn, Duke • Bernie LaSalle, U Utah • Salvadore Mungal, Duke • Anita Walden, Duke

  8. CReST Participation • Weekly Teleconferences • Thursdays: 4p Eastern, 1p Pacific • Asynchronous contributions • Use Case Authoring, Validation • Biobanking • Implemented Standards • LIMS, Biobanking, sample management… • Implemented Value Sets • Identified Sample classes

  9. Questions&Discussion Thank-you!

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