Memory circuits of the cortex and limbic systems
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Memory Circuits of the Cortex and Limbic Systems. BDNF upregulation during declarative memory formation in monkey inferior temporal cortex. Tokuyama et al. The Basics. The inferior temporal cortex stores visual pair association memory.

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Bdnf upregulation during declarative memory formation in monkey inferior temporal cortex
BDNF upregulation during declarative memory formation in monkey inferior temporal cortex

Tokuyama et al


The basics
The Basics monkey inferior temporal cortex

  • The inferior temporal cortex stores visual pair association memory.

  • Tested the hypothesis that BDNF would be upregulated in IT cortex during formation of visual pair-association memory.

  • Found BDNF was upregulated selectively in area 36 of IT cortex during PA learning, but not in areas involved in earlier stages of visual processing.

  • Suggests that BDNF contributes to reorganization of neural circuits for visual long-term memory formation in the primate


Methods three experimental strategies
Methods:Three experimental strategies monkey inferior temporal cortex

  • Intra-animal comparison of mRNA expression

  • A visual memory task as the control vs. a no-task condition

  • Trained the monkeys to first learn a “rule” or “strategy” component of the tasks with training stimulus sets; a test stimulus was then introduced for new learning of declarative components.


Increased BDNF and trk-B mRNA expression in cortical and limbic regions following formation of a social recognition memory

  • Kevin D. Board et al


The basics1
The Basics limbic regions following formation of a social recognition memory

  • Sheep recognition: olfactory evolving to visual

  • Investigate BDNF & trk-B mRNA expression 4.5 hours post partum in olfactory/visual systems


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