Repair of DS BREAKS

Repair of DS BREAKS PowerPoint PPT Presentation


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DS Break Repair Pathway'. Retrieve Sequence information from undamaged DNAUses recombinationMutants defective in recombination are UV sensitive (inefficient repair). DS DNA BREAKS (or DSBs)VERY toxicMust be dealt withHigh Mutagenic potentialExploit DSBs for immunoglobulin rearrangements. Or

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Repair of DS BREAKS

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1. Repair of DS BREAKS Homology Directed Repair Non-homology End Joining

2. DS ‘Break Repair Pathway’ Retrieve Sequence information from undamaged DNA Uses recombination Mutants defective in recombination are UV sensitive (inefficient repair) DS DNA BREAKS (or DSBs) VERY toxic Must be dealt with High Mutagenic potential Exploit DSBs for immunoglobulin rearrangements

3. Origin of DSB Direct DNA Fracture Replication fork encounters a ss break Daughter strand gap (leading/lagging strand progression halted by lesion)

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