The Damage and Repair of DNA
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The Damage and Repair of DNA. Two main types of DNA damage: *point mutations *structural changes. The molecular basis of point mutations. 1. Base substitution (mismatches) transition transversion. 2. Tautomeric shift. Gene Mutation. The molecular basis of point mutations.

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The Damage and Repair of DNA

Two main types of DNA damage:

*point mutations

*structural changes

The molecular basis of point mutations

1. Base substitution (mismatches)

transition

transversion

2. Tautomeric shift


Gene Mutation

The molecular basis of point mutations

3. Base analogs and chemical mutagens


DNA Damage

The molecular basis of structural damage

1. Hydrolytic damage

Deamination

N-glycosidic bond – very weak and easily broken

Depurination

Deamination


DNA Damage

The molecular basis of structural damage

2. Alkylation


DNA Damage

The molecular basis of structural damage

3. Oxidation and Radiation


Repairing Damages Bases

1. Mismatch repair (MMR)

Dam methylase:

MutS:


Repairing Damages Bases

1. Mismatch repair (MMR)


Repairing Damages Bases

2. Photoreactivation


Repairing Damages Bases

3. Repair of alkylation


(BER)

Repairing Damages Bases

4. Base excision repair (BER)


Repairing Damages Bases

4. Base excision repair (BER)


Repairing Damages Bases

5. Nucleotide excision repair (NER)


DNA Repair

7. Double Strand Break Repair (DSB)

Nonhomologous End-Joining (NHEJ)

Ku

XRCC4

DNA-PKcs

Artemis

Ligase


DNA Repair

8. Double Strand Break (DSB) repair (Homologous Recombination)


DNA Repair

8. Double Strand Break (DSB) repair (Homologous Recombination)


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