The Damage and Repair of DNA
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The Damage and Repair of DNA. Two main types of DNA damage: *point mutations *structural changes. The molecular basis of point mutations. 1. Base substitution (mismatches) transition transversion. 2. Tautomeric shift. Gene Mutation. The molecular basis of point mutations.

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The Damage and Repair of DNA

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The damage and repair of dna

The Damage and Repair of DNA

Two main types of DNA damage:

*point mutations

*structural changes

The molecular basis of point mutations

1. Base substitution (mismatches)

transition

transversion

2. Tautomeric shift


The damage and repair of dna

Gene Mutation

The molecular basis of point mutations

3. Base analogs and chemical mutagens


The damage and repair of dna

DNA Damage

The molecular basis of structural damage

1. Hydrolytic damage

Deamination

N-glycosidic bond – very weak and easily broken

Depurination

Deamination


The damage and repair of dna

DNA Damage

The molecular basis of structural damage

2. Alkylation


The damage and repair of dna

DNA Damage

The molecular basis of structural damage

3. Oxidation and Radiation


The damage and repair of dna

Repairing Damages Bases

1. Mismatch repair (MMR)

Dam methylase:

MutS:


The damage and repair of dna

Repairing Damages Bases

1. Mismatch repair (MMR)


The damage and repair of dna

Repairing Damages Bases

2. Photoreactivation


The damage and repair of dna

Repairing Damages Bases

3. Repair of alkylation


The damage and repair of dna

(BER)

Repairing Damages Bases

4. Base excision repair (BER)


The damage and repair of dna

Repairing Damages Bases

4. Base excision repair (BER)


The damage and repair of dna

Repairing Damages Bases

5. Nucleotide excision repair (NER)


The damage and repair of dna

DNA Repair

7. Double Strand Break Repair (DSB)

Nonhomologous End-Joining (NHEJ)

Ku

XRCC4

DNA-PKcs

Artemis

Ligase


The damage and repair of dna

DNA Repair

8. Double Strand Break (DSB) repair (Homologous Recombination)


The damage and repair of dna

DNA Repair

8. Double Strand Break (DSB) repair (Homologous Recombination)


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