Tricarboxylic Acid Cycle (TCA), Krebs Cycle. Occurs totally in mitochondria Pyruvate (actually acetate) from glycolysis is degraded to CO 2 Some ATP is produced More NADH is made NADH goes on to make more ATP in electron transport and oxidative phosphorylation
is transported to cross inner
by specific transporter.
by a multienzyme complex
(1) Thiamine pyrophosphate
- Cyclic AMP-independent protein kinase ( activated)activates phosphorylated E1 ( inactive ) & inhibits dephosphorylated ( active ) inhibit Pyr DH.
-It is rate limiting step
-isocitrate DH is activated by ADP and Ca +2 & inhibited by ATP, NADH
To OAA & 3nd NADH.