'Structure determination' presentation slideshows

Chapter 19 Oxidative phosphorylation and photophosphorylation

Chapter 19 Oxidative phosphorylation and photophosphorylation. Electron transferring via a chain of membrane bound carriers, across membrane proton gradient, ATP synthesis (with O 2 consumed or produced). Oxidative phosphorylation occurs on the convoluted inner membrane of mitochondria

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Protein Structure Similarity

Protein Structure Similarity. Secondary Structure Elements: a helices , b strands/sheets , & loops. NMR spectrometry. Structure Prediction/Determination. Computational tools Homology, threading Molecular dynamics Experimental tools. X-ray crystallography.

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Computational analysis of genome-wide expression data

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Anna Yershova Department of Computer Science Duke University February 5, 2010

Automated High-Resolution Protein Structure Determination using Residual Dipolar Couplings. Anna Yershova Department of Computer Science Duke University February 5, 2010. Feb 5 2010, NC State University. Automated Protein Structure Determination using RDCs. Introduction. Motivation.

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Archives and Information Retrieval

Archives and Information Retrieval. Lecture by; Ms. AQSAD RASHDA BIOINFORMATICS. Database indexing and specification of search terms. An index is a set of pointers to information in a database Search terms Entries: discrete coherent parcels of information.

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Structure Determination

Structure Determination. High resolution techniques - EM, NMR, X-ray Biochemical techniques -

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The System-S Approach to Automated Structure Determination: Problems and Solutions

The System-S Approach to Automated Structure Determination: Problems and Solutions. Ton Spek National Single Crystal Service Utrecht University, The Netherlands. Is a Fully Automatic Structure Determination Possible ?.

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AutoDep 4.0 A data deposition and archival system Sameer Velankar

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Yuanpeng (Janet) Huang Northeast Structural Genomics Consortium(NESG) Rutgers University

HTP Construct Optimization using Bioinformatics Coupled with Amide Hydrogen Deuterium Exchange (DXMS) and HTP NMR screening. Yuanpeng (Janet) Huang Northeast Structural Genomics Consortium(NESG) Rutgers University. PSI-1 NESG-RUTGERS HUMAN PROTEIN PRODUCTION in E. Coli (2000.7.1-2005.7.1).

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Chapter 15 Structure Determination by Spectroscopy II: UV-Vis & Mass

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Toward the automation of biological structure determination Thomas Earnest

Toward the automation of biological structure determination Thomas Earnest Berkeley Center for Structural Biology Physical Biosciences Division Lawrence Berkeley National Laboratory. Manual mounting and alignment. micro-scope. cryostream. gripper. goniometer/ XYZ stage. collimator/

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Molecule of the Week ATP Synthase

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Drug Targets their role in drug design / discovery

Drug Targets their role in drug design / discovery. At the end of the 20 th C the set of drug targets for the pharmaceutical industry was ~ 500, 45% cell membrane receptors (including GPCR) 28% enzymes 11% hormone 5% ion channels 2% nuclear receptors 2% DNA 7% Unknown targets.

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High-Throughput Crystallography at Monash

High-Throughput Crystallography at Monash. Noel Faux Dept of Biochemistry and Molecular Biology Monash University. Structural Biology Pipe Line. Cloning. Purification. X-ray diffraction. Determine the structure. Expression. Crystallisation. Australian synchrotron online in 2007.

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CRISTALLOGRAFIA A RAGGI X

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Bioinformatics Applications and Workloads

Bioinformatics Applications and Workloads. Collaboration with the BMRB. The BioMagResBank is a repository for data from NMR spectroscopy on proteins. Two main efforts: - Weekly BLAST run - Protein Structure Determination. BLAST. Framework in PERL completely automates the process:

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Substituted Benzenes

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Drug Target Structure

Drug Target Structure. Physical methods of structure determination. Drug Targets (1). Biomolecular Drug Target Receptor Enzyme Transcription Factor Antigen Gene sequence. Drug Type agonist / antagonist enzyme inhibitor covalent / non-covalent Antibody

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Six plasmids for NC5 sample expression and 2D [ 1 H, 15 N] HSQC screening Rossmann2x3_58: OR25

Red: Design. Red: Design. Green: NMR, PDB 2KPO. Green: NMR, PDB 2KI8. H2. L1. F44. L41. V31. L37. Y3. L5. I7. V4. L2. I14. L28. I6. H1. NMR:green , PDB 2KI8. Design:red. L69. H3. I75. A70. A66. I51. V57. L63. I55. V53. V82. L54. L56. F95. A88. H4. I92.

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