Molecule of the week atp synthase
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Molecule of the Week ATP Synthase. ...a nanoscale machine. Two molecular motors / generators Enzyme Ion pump. Function: Synthesize ATP / Create proton gradient. ATP – Adenosine triphosphate. Cellular energy „currency“ DNA replication / transcription Cell signalling. ADP + P i → ATP.

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Molecule of the Week ATP Synthase

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Molecule of the week atp synthase

Molecule of the Week

ATP Synthase


A nanoscale machine
...a nanoscale machine

  • Two molecular motors / generators

  • Enzyme

  • Ion pump

Function:Synthesize ATP /Create proton gradient


Atp adenosine triphosphate
ATP – Adenosine triphosphate

  • Cellular energy „currency“

  • DNA replication / transcription

  • Cell signalling


Adp p i atp
ADP + Pi→ ATP


Atp production
ATP – Production

  • Photosynthesis


Atp production1
ATP – Production

  • Photosynthesis

  • Aerobic respiration


Atp production2
ATP – Production

  • Photosynthesis

  • Aerobic respiration

  • Anaerobic respiration


Structure determination of f1
Structure determination of F1

  • “Structure at 2.8 Å resolution of F1-ATPase from bovine heart mitochondria”,Abrahams, Leslie, Lutter and Walker,Nature Vol. 370, 1994

  • Boyer and Walker shared half of the 1997 Nobel Prize in Chemistry


Molecular structure
Molecular structure

Cell membrane

Inside cell organelle

Diameter: 9 nm



Fo part1
FO part

Ion motor





F1 part3
F1 part

Binding change / „Flip-flop“ mechanism


F1 part4
F1 part

Binding change / „Flip-flop“ mechanism



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