Molecule of the week atp synthase
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Molecule of the Week ATP Synthase PowerPoint PPT Presentation


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Molecule of the Week ATP Synthase. ...a nanoscale machine. Two molecular motors / generators Enzyme Ion pump. Function: Synthesize ATP / Create proton gradient. ATP – Adenosine triphosphate. Cellular energy „currency“ DNA replication / transcription Cell signalling. ADP + P i → ATP.

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Molecule of the Week ATP Synthase

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Molecule of the Week

ATP Synthase


...a nanoscale machine

  • Two molecular motors / generators

  • Enzyme

  • Ion pump

Function:Synthesize ATP /Create proton gradient


ATP – Adenosine triphosphate

  • Cellular energy „currency“

  • DNA replication / transcription

  • Cell signalling


ADP + Pi→ ATP


ATP – Production

  • Photosynthesis


ATP – Production

  • Photosynthesis

  • Aerobic respiration


ATP – Production

  • Photosynthesis

  • Aerobic respiration

  • Anaerobic respiration


Structure determination of F1

  • “Structure at 2.8 Å resolution of F1-ATPase from bovine heart mitochondria”,Abrahams, Leslie, Lutter and Walker,Nature Vol. 370, 1994

  • Boyer and Walker shared half of the 1997 Nobel Prize in Chemistry


Molecular structure

Cell membrane

Inside cell organelle

Diameter: 9 nm


FO part


FO part

Ion motor


F1 part


F1 part


F1 part


F1 part

Binding change / „Flip-flop“ mechanism


F1 part

Binding change / „Flip-flop“ mechanism


Questions ?


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