'Protein folds' presentation slideshows

Protein Tertiary Structure Prediction

Protein Tertiary Structure Prediction. Structural Bioinformatics. The Different levels of Protein Structure. Primary: amino acid linear sequence. Secondary: ? -helices, ? -sheets and loops. Tertiary : the 3D shape of the fully folded polypeptide chain.

894 views • 42 slides

Protein Tertiary Structure Prediction

Protein Tertiary Structure Prediction. Structural Bioinformatics. The Different levels of Protein Structure. Primary: amino acid linear sequence. Secondary: ? -helices, ? -sheets and loops. Tertiary : the 3D shape of the fully folded polypeptide chain.

421 views • 42 slides

Pairwise sequence alignments

Pairwise sequence alignments. Dynamic programming (Needleman-Wunsch), finds optimal alignment Heuristics: Blast (Altschul et al) does not guarantee finding optimal alignment, but fast. Pairwise sequence alignments. AP L F V A ---- ITRS DD AP V F I A GDTR ITRS EE Assumptions:

693 views • 41 slides

Protein Structure and Function Prediction

Protein Structure and Function Prediction. Predicting 3D Structure. Outstanding difficult problem. Comparative modeling (homology) Fold recognition (threading). Based on Sequence. Based on Secondary Structure. Based on Sequence. Comparative Modeling.

536 views • 30 slides

Protein structure determination & prediction

Protein structure determination & prediction. Tertiary protein structure: protein folding. Three main approaches: [1] experimental determination (X-ray crystallography, NMR) [2] Comparative modeling (based on homology) [3] Ab initio (de novo) prediction

443 views • 18 slides

Structural Bioinformatics

Structural Bioinformatics. R. Sowdhamini National Centre for Biological Sciences Tata Institute of Fundamental Research Bangalore, INDIA. Prediction with inputs from Structural Bioinformatics. Genome-wide analysis of protein families. Evolutionary relationships amongst proteins.

331 views • 17 slides

Structural Bioinformatics

Structural Bioinformatics. R. Sowdhamini National Centre for Biological Sciences Tata Institute of Fundamental Research Bangalore, INDIA. Prediction with inputs from Structural Bioinformatics. Genome-wide analysis of protein families. Evolutionary relationships amongst proteins.

245 views • 17 slides

PROTEIN PHYSICS LECTURE 25

PROTEIN PHYSICS LECTURE 25. PROTEINS AT ACTION. Preferential binding of TS: RIGID enzyme. Preferential binding of TS: RIGID enzyme. F = k 1 x 1 = - k 2 x 2 E i = ( k i /2 )( x i ) 2 = F 2 / ( 2k i )

167 views • 16 slides

The Potts Model Partition Function:

450 views • 15 slides