Structural Bioinformatics. R. Sowdhamini National Centre for Biological Sciences Tata Institute of Fundamental Research Bangalore, INDIA. Prediction with inputs from Structural Bioinformatics. Genome-wide analysis of protein families. Evolutionary relationships amongst proteins.
National Centre for Biological Sciences
Tata Institute of Fundamental Research
Genome-wide analysis of protein families
Evolutionary relationships amongst proteins
Design of novel protein folds
Design of new function to an existing
Sensitive sequence searches: profiles and HMMs
Large scale computing in cluster environment
Successful design of novel folds and new
Mechanisms of thermal adaptationrevealed from the genome of the antarctic Archaea Methanogenium frigidum and Methanococcoides burtonii. Saunders et al., Genome Res 2003 (7):1580-8Example of recent advances: 1Genome-wide survey
Using multiple sequence correlation analysis to characterize functionally important protein regions.
Saraf et al., Protein Eng 2003
16:397-406.Examples of recent advances: 2Function prediction
Interrogating protein interaction networks through structural biology. Aloy and Russell, Proc Natl Acad Sci U S A. 2002, 99:5896-901.Examples of recent advances: 3Protein-protein interactions
Discovery of a potent and selective protein kinase CK2 inhibitor by high-throughput docking. Vangrevelinghe et al.,J Med Chem. 2003, 46:2656-62.
Structural modes of stabilization of permissive phosphorylation sites in protein kinases: distinct strategies in Ser/Thr and Tyr kinases. Krupa et al., J Mol Biol. 2004, 339:1025-39.Examples of recent advances: 6Docking and inhibitor design
Protein structure prediction|||||||
Secondary structure prediction||||||||||
Side chain prediction||
Protein structure comparisons ||||||||||
Protein-RNA interactions ||
Protein structure analysis|||||
Function prediction |||||
Visualisation server |||
How does a protein fold?
Papers in this session
Can functionally important residues
Can structure prediction lead
to function prediction?
How does a protein recognise its ligand?
Paper in this session
What happens subsequent
to ligand binding?
How do protein-protein interactions happen?
Paper in this session