'Ph pka' presentation slideshows

Dennis Paul, Ph.D. Department of Pharmacology 504-568-4740 rwainf@lsuhsc

BIOLOGICAL SYSTEM A Gastrointestinal and Hepatic Systems Regulation of Drug Transport, Absorption, Distribution, Excretion and Metabolism. Dennis Paul, Ph.D. Department of Pharmacology 504-568-4740 rwainf@lsuhsc.edu. Principles of Pharmacology. Common processes and mechanisms whereby:

1.01k views • 101 slides

Principle of Pharmacology Pharmacokinetics Dr. Guangyu Wu Department of Pharmacology

Principle of Pharmacology Pharmacokinetics Dr. Guangyu Wu Department of Pharmacology LSU Health Sciences Center New Orleans, LA. Pharmacodynamics Drug actions and their mechanisms. DRUGS. RECEPTORS. RECEPTORS. RECEPTORS. PHARMACOLOGICAL RESPONSES. Pharmacokinetics

1.21k views • 88 slides

Water

393 views • 39 slides

Ionic Properties of Amino Acids

Ionic Properties of Amino Acids . Lab B.1, pages 48 to 64 In lab manual. Bronsted Acids and Bases. Have groups which can accept or donate hydronium ions (H + ) Have acid dissociation constants K a At pK a ratio of charged to uncharged is 1

770 views • 28 slides

Physicochemical properties in relation to biological activity

Physicochemical properties in relation to biological activity. Drug distribution A drug is a chemical molecule, following introduction into the body must pass through many barriers before it reach the site of action. At the receptor the following equilibrium usually holds:

999 views • 28 slides

Physicochemical properties in relation to biological activity

Physicochemical properties in relation to biological activity. Drug distribution A drug is a chemical molecule, following introduction into the body must pass through many barriers before it reach the site of action. At the receptor the following equilibrium usually holds:

3.96k views • 28 slides

Physicochemical properties in relation to biological activity

Physicochemical properties in relation to biological activity. Drug distribution A drug is a chemical molecule, following introduction into the body must pass through many barriers before it reach the site of action. At the receptor the following equilibrium usually holds:

598 views • 28 slides

Physicochemical properties in relation to biological activity

Physicochemical properties in relation to biological activity. Drug distribution A drug is a chemical molecule, following introduction into the body must pass through many barriers before it reach the site of action. At the receptor the following equilibrium usually holds:

447 views • 28 slides

pKa concepts

513 views • 16 slides

Determine Ka of a Weak Acid

Determine Ka of a Weak Acid. Determine Ka of a weak acid. The ionization of a weak acid can be shown by the following equation: HA (aq) + H 2 O (l) ? H 3 O + (aq) + A - (aq) (Eqn. 1) Since an equilibrium exists, an equilibrium constant, Ka, can be written as:

250 views • 14 slides

Determine Ka of a Weak Acid

Determine Ka of a Weak Acid. Determine Ka of a weak acid. The ionization of a weak acid can be shown by the following equation: HA (aq) + H 2 O (l) ? H 3 O + (aq) + A - (aq) (Eqn. 1) Since an equilibrium exists, an equilibrium constant, Ka, can be written as:

479 views • 14 slides

Preparation of buffers

Preparation of buffers. Definition. A 1M solution of sulfuric acid contains 98.06 g of sulfuric acid in 1 liter of total solution. "mole" is an expression of amount "molarity" is an expression of concentration. "Millimolar", mM, millimole/L. A millimole is 1/1000 of a mole .

266 views • 11 slides

Conjugate Acid-base pairs

Conjugate Acid-base pairs. Acetic acid. Acetate. Protonated acid (HA). Conjugated base (A - ). H.H. When pH= pKa , then: [A - ]/[HA] = 1, log 10 (1)= 0. When pH < pKa , then: [A - ] < [HA]. When pH > pK a , then: [A - ] > [HA]. Buffer = HA + A-. X. If pK a = 2.5, then pH=?.

1.47k views • 8 slides