'Minor groove' presentation slideshows

Exploring Nucleic Acid Structures

Exploring Nucleic Acid Structures . Nucleic Acid Building Blocks: Nucleotides. Base. Sugar. Phosphate. Bases. Pyrimidines and purines Positions of hydrogens key to recognition. DNA vs. RNA. Bases Purines and Pyrimidines Bases in DNA (dA, dT, dG, dC) Bases in RNA (A, U, G, C) Sugars

920 views • 78 slides

Chapter 2: The Structure of DNA

Chapter 2: The Structure of DNA. Imagine yourself inside one of those cooling DNA solutions, observing the rebirth of beautifully undulating, semirigid, double-helical threads from the jumble of billions of intertwisted single strands. It is a mind reeling spectacle.

1.07k views • 62 slides

DNA STRUCTURE

DNA STRUCTURE. DNA is composed of polynucleotide chains. The helical structure of DNA. Formation of Nucleotides. Structure of polynucleotide polymer. Each base has its preferred tautomeric form. Purine and Pyrimidine.

2.16k views • 56 slides

1- B DNA -- Genome

1- B DNA -- Genome 2- Double helix -- Relaxed form 3- Antiparallel -- Super coil

635 views • 52 slides

What is the flow of information through the cell?

687 views • 43 slides

MCB 110:Biochemistry of the Central Dogma of MB

MCB 110:Biochemistry of the Central Dogma of MB. Part 1. DNA replication, repair and genomics (Prof. Alber). Part 2. RNA & protein synthesis. Prof. Zhou. Part 3. Membranes, protein secretion, trafficking and signaling. Prof. Nogales. MCB 110:Biochemistry of the Central Dogma of MB.

730 views • 43 slides

A hierarchical model for evolution of ribosomal RNA

647 views • 43 slides

Nucleosome Positioning

Nucleosome Positioning. Histones and DNA Bending. DNA packaging. 3 X 10 9 base pairs in human genome ~1 m if unraveled Compacted into nucleus 100 m m in diamter. Histones. Histones. PDBID = 1KX3. Nucleosome Arrays. Dorigo B, et al. Science. 2004 306 (5701):1571-3.

819 views • 34 slides

Lec 3: More Nucleic Acids, Proteins.

381 views • 28 slides

PRECLINICAL PHARMACOLOGY & TOXICOLOGY IN CANCER DRUG DEVELOPMENT

PRECLINICAL PHARMACOLOGY & TOXICOLOGY IN CANCER DRUG DEVELOPMENT. Joseph M. Covey, Ph.D. Toxicology & Pharmacology Branch DTP, DCTD, NCI. Preclinical Pharmacology & Toxicology: Why ?. Balance of : Regulatory Issues Need for information Science Practical Considerations

1.01k views • 24 slides

Exploring Nucleic Acid Structures

Exploring Nucleic Acid Structures . Chemistry and Chemical Biology Rutgers University. Nucleic Acid Building Blocks: Nucleotides. Base. Sugar. Phosphate. Chemistry. Bases Purines and Pyrimidines Bases in DNA (dA, dT, dG, dC) Bases in RNA (A, U, G, C) Sugars

322 views • 20 slides

Ongoing and Future Projects

Ongoing and Future Projects. Tianyin Zhou 4/9/2011. 1.FIS. Two binding sites: the binding affinity(left) 1000x stronger the binding affinity(right) Why? Left: The intrinsic shape of free DNA == Bound DNA ? more easily binding

371 views • 17 slides

BIBC 100 Midterm 2 Review Session

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Analysis of Differential Gene Expression in a Myotonic Dystrophy Tissue Cultue Model

Analysis of Differential Gene Expression in a Myotonic Dystrophy Tissue Cultue Model. Matthew Tanner Berglund Lab, Institute of Molecular Biology CIS 407 Dec. 2 nd , 2013. Myotonic Dystrophy 1 (DM1). Symptoms

268 views • 16 slides

Gene structure DNA replication

Gene structure DNA replication. Figure 7.4A. Figure 7.5. The DNA double helix has grooves: a wide major groove and a narrow minor groove. - These provide DNA-binding proteins access to base sequences. DNA Structure. Figure 7.6. RNA differs from DNA: - Usually single-stranded

315 views • 16 slides

Cs34: Specificity II - Specific aminoacylation of tRNA

NTP metabolism and transduction. Cs34: Specificity II - Specific aminoacylation of tRNA. Biochemistry 655 4 April 2011. Goals. Introduce the aminoacyl-tRNA synthetase class division Polarity of substrate amino acids

243 views • 15 slides

Bringing True Novelty to the Anti-Infectives Space New Class of Antibacterials Based on

349 views • 13 slides

Nucleic Acid-Small Molecule Interactions Blackburn & Gait Ch. 9

Nucleic Acid-Small Molecule Interactions Blackburn & Gait Ch. 9 Know three main ways nucleic acids interact with small molecules Understand Manning/Rich hypothesis and counterion condensation theory Understand electrostatic interactions between proteins and NA

268 views • 13 slides

Identification and comparison of indirect readout sequences in mycobacteriophage

By: Kristen Wade. Identification and comparison of indirect readout sequences in mycobacteriophage. What are indirect readout sites (IDRS)?. Short (~4 bps), non-contacted DNA sequences that do not directly interact with the binding protein.

170 views • 12 slides

3) Name the 5 common nitrogen bases found in DNA?___________, ________, ________, _______, _________

Quiz 3: Biol 302 2012. Part 1: Structure of single complete gene with 5 exons. 5pts ExtraCredit. Name:_______________. 1. 2. 3. 4. 5. How many of these exons will EVENTUALLY end up in a mRNA?_________________________

128 views • 2 slides