'Knockout mice' presentation slideshows

Cora Lee Wetherington, Ph.D. Women & Gender Research Coordinator National Institute on Drug Abuse National Advisory

Cora Lee Wetherington, Ph.D. Women & Gender Research Coordinator National Institute on Drug Abuse National Advisory Council on Drug Abuse September 20, 2006. The Pervasiveness of Sex/Gender Differences in Drug Abuse. Gender Differences in Drug Abuse. The Numbers Animal Models

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p. 463

p. 463. Ch. 20. AIDS and Other Immunodeficiencies. Primary: affects either adaptive or innate immunity inherited developmental Secondary: exposure to viruses and other agents Consequence: infection, life-threatening . p. 494. Severity depends on the number and type of

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Transgenic Animals

Transgenic Animals. Dr. Azhar Chishti Department of Medical Biochemistry. LECTURE OUTLINES. Transgenic animals Overview of transgenic mice How to create transgenic animals Transfer of DNA into eukaryotic cells Confirming mutation in germ cells Overview of knockout mice

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Outline

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Treating NASH with Fibrosis

Vivek Saraswat Sanjay Gandhi Postgraduate Institute Lucknow India . Treating NASH with Fibrosis. Pharmacological Therapies for NASH. (Torres & Harrison, 2008). Pharmacological Therapies for NASH. Currently no effective therapy is available for treating or preventing fibrosis in NASH

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Dr Samir S. Ayoub

New and novel uses for paracetamol. Studies on the mechanism of the paracetamol -induced hypothermia and clinical Relevance. Dr Samir S. Ayoub. Paracetamol. Analgesic and anti-fever drug with weak anti-inflammatory effects Used clinically for over a century

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Models in Genetics

Models in Genetics. Of Mice and Men Patricia Sidelsky BS/MS Biology Cherokee High School Marlton, NJ. What is a Genetic Model ?. Genes on chromosomes have been mapped Genome has been sequenced Significant for genetic content - relevance to man and society

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DRUG-DRUG INTERACTIONS IN VIVO AND IN VITRO STUDIES: Focus on Transporters

DRUG-DRUG INTERACTIONS IN VIVO AND IN VITRO STUDIES: Focus on Transporters. Background: Focus on P-gp. Other Transporters. Questions:. Multiple Membrane Transporters in Hepatocyte Work in Concert With Enzymes to Mediate Drug Elimination. SLC. DME. Drug. Metabolite. ABC.

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Animal Behaviour

Animal Behaviour. BIOL 3100. Artificial Selection. Captive breeding experiment Breed males that start their fall migration late with females that start their fall migration late. Artificial selection.

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Hematopoietin/Interferon Signaling

Hematopoietin/Interferon Signaling. Schindler et al pdf. JH7. JH6. JH5. JH4. JH3. JH2/ y K. JH1/TK. 500. 0. 100. 600. 700. 1000. 1100. 1200. 800. 300. 400. 900. 200. Expressed in all tissues . Expressed in hemato- poietic tissues. Janus Kinase Family. Tyk2 Jak1 Jak2

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Knockout and transgenic mice: uses and abuses

Knockout and transgenic mice: uses and abuses. To create: homologous integration of DNA in embryonic stem cells Inserted DNA replaces normal gene at normal site on chromosome Usually homozygote for best expression Purpose: replace normal gene.

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Prostatic acid phosphatase (PAP) - a potent analgesic for treating pain

Prostatic acid phosphatase (PAP) - a potent analgesic for treating pain. Mark J. Zylka University of North Carolina at Chapel Hill. More Americans suffer from chronic pain than heart disease, diabetes and cancer combined. Inflammatory and surgical pain

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PhIP-induced Mutation in Mlh1 -deficient Mice

PhIP-induced Mutation in Mlh1 -deficient Mice. Stacy Hill. Significance. 2-5% of all colorectal cancer cases in humans result from a genetic predisposition called hereditary nonpolyposis colorectal cancer (HNPCC). HNPCC is the most commonly inherited form of colorectal cancer.

430 views • 19 slides

P57 Kip2 and Beckwith- Wiedemann Syndrome

Tim Lockney. P57 Kip2 and Beckwith- Wiedemann Syndrome . What is p57?. Alias: CDKN1C 316 Amino Acids long Localized in the Nucleus Important during development Localized to Chromosome 11p15.5. Matsuoka et al. What type of protein is p57?. CDK-inhibitor p 21 Family ? ?

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P57 Kip2 and Beckwith- Wiedemann Syndrome

Tim Lockney. P57 Kip2 and Beckwith- Wiedemann Syndrome. What is p57?. Alias: CDKN1C 316 Amino Acids long Localized in the Nucleus Important during development Localized to Chromosome 11p15.5. Matsuoka et al. What type of protein is p57?. CDK-inhibitor p21 Family ? ?

272 views • 16 slides

Conserved Through the Ages: GATA-1 and Friend of GATA-1 (FOG-1) Interactions with DNA

Conserved Through the Ages: GATA-1 and Friend of GATA-1 (FOG-1) Interactions with DNA. Student Researchers : Esmeralda Ambriz , Linnea Esberg , Nicole Fischer, Amy Ramirez Faculty Advisor: Dr. Colleen Conway ~Mount Mary College Resear ch Mentor : Dr. Michele Battle

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Chem 509 Signal Transduction Winter 2012

Chem 509 Signal Transduction Winter 2012. Lecture 5. 1. Two-hybrid assay. Created by Song and Fields. Concept adapted from the studies of Ptashne Modular nature of proteins. Companies now make kits for this. 2. IP Kinase activity assay Assay employs immunoprecipitation technique.

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Chem 509 Signal Transduction Winter 2012

Chem 509 Signal Transduction Winter 2012. Lecture 5. 1. Two-hybrid assay. Created by Song and Fields. Concept adapted from the studies of Ptashne Modular nature of proteins. Companies now make kits for this. 2. IP Kinase activity assay Assay employs immunoprecipitation technique.

250 views • 12 slides

NEUROINFLAMMATION

Motoric abnormalities. Generation of Neural specific knockout. A. B. A.

389 views • 1 slides