'Gene silencing' presentation slideshows

RNAi Overview Mechanism Role in heterochromatin formation

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Additional Transformation Topics

858 views • 61 slides

Intellectual Property and Food Security

Intellectual Property and Food Security. Professor Michael Blakeney, Australian Global Studies Research Centre, UWA. Food Insecurity.

648 views • 48 slides

Course Title: Epigenetics

Course Title: Epigenetics. Lecture Titles: Lecture I: General Overview and History of Epigenetics Lecture II: DNA methylation Lecture III: Alteration in DNA methylation and its transgenerational inheritance Lecture IV: DNA methylation and genome stability

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Advantages of C. elegans : 1. rapid life cycle 2. hermaphrodite 3. prolific reproduction 4. transparent 5. only ~1000 c

Advantages of C. elegans : 1. rapid life cycle 2. hermaphrodite 3. prolific reproduction 4. transparent 5. only ~1000 cells 6. laser ablation 7. complete cell lineage map - Horvitz 8. Genetics - Brenner. Gene silencing and RNA viruses share potential to produce dsRNA.

720 views • 32 slides

The mechanism of RNAi

The mechanism of RNAi. by Renchang. Guo S et al, a gene required for establishing polarity in C. elegans embryos, encoding a putative Ser/Thr kinase that is asymmetrically distributed, cell, 1995, 81:611. Fire Andrew, et al, Potent and specific genetic interference

539 views • 32 slides

Advantages of C. elegans : 1. rapid life cycle 2. hermaphrodite 3. prolific reproduction

Advantages of C. elegans : 1. rapid life cycle 2. hermaphrodite 3. prolific reproduction 4. transparent 5. only ~1000 cells 6. laser ablation 7. complete cell lineage map 8. genetics. RNA interference: A type of gene regulation Involving small RNA molecules

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RNAi

RNAi. C. elegans and siRNA Penetrance and Expressivity. transcription. Alt. Splicing Alt. Poly-A, Alt. Translation Start. translation. Central Dogma addendum. DNA. RNA. Transcription Factors. Protein. TGS. transcription. PTGS. translation. Central Dogma addenda. DNA.

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Post-transcriptional Control:

DNA. RNA. Protein. Dogmatic View of Gene Expression. Post-transcriptional Control:. Quantitative Control: Levels of mRNA not proportional to levels of mRNA synthesized or protein produced Qualitative Control: More than one protein from a single gene

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RNA interference

RNA interference. http://en.wikipedia.org/wiki/RNA_interference Definition: RNA interference (RNAi) is a mechanism where the presence of certain fragments of ds RNA interferes with the expression of a particular gene which shares a homologous sequence with this dsRNA.

819 views • 17 slides

Avoiding Gene Silencing

Avoiding Gene Silencing. Integration site and base composition. Plant genomes are mosaics of compositionally homogenous DNA segments with

422 views • 14 slides

Functional Genomics: The Knockout Approach

Functional Genomics: The Knockout Approach. Assessing physiological role of specific gene products. Eliminate given gene product and what happens? Gene silencing Insertional mutagenesis PCR Transposon T-DNA? Non-polar mutations (insert and recombine out). Gene silencing.

353 views • 14 slides

rasiRNAs: a class of small regulatory RNAs

rasiRNAs: a class of small regulatory RNAs. Jasmine Lau 4 May 2009. The Family of small RNAs. Small noncoding regulatory RNAs. Shorter length 20-25 nucleotides. Longer length 24-27 nucleotides. piwi-interacting RNAs (piRNAs). small interfering RNAs (siRNAs). microRNAs (miRNAs).

308 views • 12 slides

mRNA1 no introns. protein isoform1. genomic DNA. pre-mRNA with introns. mRNA2 no introns. protein isoform2. non-coding RNA genes.

712 views • 12 slides

Rhiana Lau MMG C174 Professor Simpson

An RNA-directed nuclease mediates post-transcriptional gene silencing in Drosophila cells Scott M. Hammond, Emily Bernstein, David Beach, and Gregory J. Hannon. Rhiana Lau MMG C174 Professor Simpson. Gene Silencing.

225 views • 12 slides

Gene silencing in plants.

Transcription. Transcription. Poly A. Poly A. Poly A. GFP. GFP. GFP. intron. PFG. gene silencing mRNA degradation. Translation. DICER. GFP. RISC. PFG. Poly A. CAP. CAP. CAP. CAP. CAP. Poly A. DICER. GFP. p 35S. p 35S. GFP. intron. PFG. No Fluorescence. Fluorescence.

1.37k views • 8 slides

Gene silencing in plants.

Transcription. Transcription. Poly A. Poly A. Poly A. GFP. GFP. GFP. intron. PFG. gene silencing mRNA degradation. Translation. DICER. GFP. RISC. PFG. Poly A. CAP. CAP. CAP. CAP. CAP. Poly A. DICER. GFP. p 35S. p 35S. GFP. intron. PFG. No Fluorescence. Fluorescence.

291 views • 8 slides

RNAi - Technologies, Markets and Companies

Bharat Book Presents"RNAi - Technologies, Markets and Companies" compares RNAi with other antisense approaches using oligonucleotides, aptamers, ribozymes, peptide nucleic acid and locked nucleic acid.

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Figure 8. A Model for Human RISC Function Involving miRNA and siRNA

Figure 8. A Model for Human RISC Function Involving miRNA and siRNA. Chu C-y, Rana TM (2006) Translation Repression in Human Cells by MicroRNA-Induced Gene Silencing Requires RCK/p54. PLoS Biol 4(7): e210. doi:10.1371/journal.pbio.0040210

105 views • 1 slides

Arabidopsis and Gene Silencing; Effects of Acid Rain

Arabidopsis and Gene Silencing; Effects of Acid Rain. By: Becky Rupnow, Jennifer Kosmicki, Margot Binetti, and Annie Kuczkowski. Abstract:

133 views • 1 slides