Cre

Sep 17, 2014

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B. FRT. FRT. Smo c. Exon1. Neo. Smo. A. loxP. loxP. X. Wnt1-Cre. NCC-specific removal of Hh signaling ( Wnt1-Cre;Smo n/c ). Cre. Wnt1 enhancer. Wnt1 promotor. X. C. Neo/4xpA. SmoM2. ROSA26. loxP. loxP. R26SmoM2. NCC-specific activation of Hh signaling ( Wnt1-Cre;R26SmoM2 ).

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Cre

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B. FRT FRT Smoc Exon1 Neo Smo A. loxP loxP X Wnt1-Cre NCC-specific removal of Hh signaling (Wnt1-Cre;Smon/c) Cre Wnt1 enhancer Wnt1 promotor X C. Neo/4xpA SmoM2 ROSA26 loxP loxP R26SmoM2 NCC-specific activation of Hh signaling (Wnt1-Cre;R26SmoM2) Wnt1-Cre;R26R-LacZ
E10.5 E9.5 C D B A
Wnt1-Cre; R26SmoM2 Wt A G F E D C B H J I E10.5 E12.5 E18.5 NCC
NCC Shh Ptch1 FNP 1BA 2BA Foxc2 Foxd1 Foxf1 Foxd2 Foxf2 A B D E F G H I J C