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Epidemiology and Control of Dengue Fever in Key West

Dana A. Focks, Ali M. Messenger, Kelli L. Barr, Department of Environmental and Global Health College of Public Health and Health Professions and the Emerging Pathogens Institute University of Florida. Epidemiology and Control of Dengue Fever in Key West. Dengue in Key West.

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Epidemiology and Control of Dengue Fever in Key West

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  1. Dana A. Focks, Ali M. Messenger, Kelli L. Barr, Department of Environmental and Global Health College of Public Health and Health Professions and the Emerging Pathogens Institute University of Florida Epidemiology and Control of Dengue Fever in Key West

  2. Dengue in Key West • Key West residents experienced locally-acquired dengue (DENV) for the first time since 1934 in 2009 (26 cases) and in 2010 (63). • Answering some epidemiologic questions may help us with control: • Why did DENV occur: • Only during 2009 and 2010? • And largely in the Old Town and Midtown sections of Key West? • Cryptic source of Ae. aegypti?

  3. Magnitude of DENV introductions due to travelers from dengue endemic areas

  4. Dengue Serotypes 1-4 Exhibit Unique Host Specificity In Vitro

  5. Seroprevalence and Risk Factors • Seroprevalence of anti-dengue IgG has not been established following the outbreaks in 2009-2010 • Risk of secondary infection has not been predicted • Culturally relevant risk factor analysis has never been conducted for DENV in the US

  6. Understanding the spatial distribution of dengue • Hypothesis: Cases were largely confined to Old Town and Midtown due to: • Tourism venues • Undetected and untreated cisterns common to the sections of town. • Workplaces of residents are an alternate exposure site.

  7. Publications • Dengue Serotypes 1-4 Exhibit Unique Host Specificity In Vitro - in review Journal of Vector Borne and Zoonotic Diseases • Traveler introductions perpetuated local transmission of dengue virus in Key West, FL 2009-2010 – submitted for Emerging Infectious Diseases • Predicting the risk of secondary dengue infections in residents of Key West, FL – in preparation for PLOS NTD • Identification of risk factors for dengue infections in South Florida – in preparation for Journal of Clinical Virology

  8. Impact • This work will result in: • Enhanced efficacy of vector control • Accurate dengue models • Novel in vitro systems • Identify population at risk for ADE • Predict effect of future introductions • Culturally relevant risk factors

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