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Sequence Alignments In Bioinformatics Lecture by: Ms AQSAD RASHDAPowerPoint Presentation

Sequence Alignments In Bioinformatics Lecture by: Ms AQSAD RASHDA

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Sequence Alignments In Bioinformatics Lecture by: Ms AQSAD RASHDA

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Sequence Alignments In Bioinformatics Lecture by: Ms AQSAD RASHDA

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Sequence Alignments In BioinformaticsLecture by: Ms AQSAD RASHDA

Comparative Analysis

Sequence alignment

Pairwise alignments

Multiple alignments

Similarity

Homology

The changes: Substitutions, insertions, and deletions.

Gaps

Dynamic programming

Needleman-Wunsch algorithm

Smith-Waterman algorithm

SIM algorithm: A program called lalign

Substitution matrix for proteins

Isoleucine for valine

Serine for threonine

Alignment scores

Point accepted mutation (PAM) model of evolution

Background frequencies

Substitution frequencies (target frequencies) in related proteins