Sequence alignments in bioinformatics lecture by ms aqsad rashda
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Sequence Alignments In Bioinformatics Lecture by: Ms AQSAD RASHDA. Sequence Analysis. Comparative Analysis Sequence alignment Pairwise alignments Multiple alignments. THE EVOLUTIONARY BASIS OF SEQUENCE ALIGNMENT. Similarity Homology

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Sequence Alignments In Bioinformatics Lecture by: Ms AQSAD RASHDA

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Sequence alignments in bioinformatics lecture by ms aqsad rashda

Sequence Alignments In BioinformaticsLecture by: Ms AQSAD RASHDA


Sequence analysis

Sequence Analysis

Comparative Analysis

Sequence alignment

Pairwise alignments

Multiple alignments


The evolutionary basis of sequence alignment

THE EVOLUTIONARY BASIS OF SEQUENCE ALIGNMENT

Similarity

Homology

The changes: Substitutions, insertions, and deletions.

Gaps


Global alignment

Global alignment


Local alignment

Local alignment


Pairwise alignment dot matrix

Pairwise alignmentDot-matrix


Filtered dot matrix

Filtered Dot Matrix


Protein dot plots

Protein Dot Plots


Optimal alignment methods

OPTIMAL ALIGNMENT METHODS

Dynamic programming

Needleman-Wunsch algorithm

Smith-Waterman algorithm

SIM algorithm: A program called lalign


Needleman wunsch algorithm

Needleman-Wunsch algorithm


Smith waterman algorithm

Smith-Waterman algorithm


Lalign program

lalign Program


Substitution scores and gap penalties

SUBSTITUTION SCORES AND GAP PENALTIES

Substitution matrix for proteins

Isoleucine for valine

Serine for threonine

Alignment scores

Point accepted mutation (PAM) model of evolution

Background frequencies

Substitution frequencies (target frequencies) in related proteins


The pam250 scoring matrix

The PAM250 scoring matrix


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