Sequence Alignments In Bioinformatics Lecture by: Ms AQSAD RASHDA. Sequence Analysis. Comparative Analysis Sequence alignment Pairwise alignments Multiple alignments. THE EVOLUTIONARY BASIS OF SEQUENCE ALIGNMENT. Similarity Homology
The changes: Substitutions, insertions, and deletions.
SIM algorithm: A program called lalign
Substitution matrix for proteins
Isoleucine for valine
Serine for threonine
Point accepted mutation (PAM) model of evolution
Substitution frequencies (target frequencies) in related proteins