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Wound Healing, Tissue Engineering and New Materials

Wound Healing, Tissue Engineering and New Materials. Roger W. Yurt, M.D. William Randolph Hearst Burn Center. Burn Center. Clinical care of burn injured patients including smoke inhalation and carbon monoxide poisoning

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Wound Healing, Tissue Engineering and New Materials

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  1. Wound Healing, Tissue Engineering and New Materials Roger W. Yurt, M.D. William Randolph Hearst Burn Center

  2. Burn Center • Clinical care of burn injured patients including smoke inhalation and carbon monoxide poisoning • Clinical care of patients with acute and chronic wounds – eg, purpura fulminans • Clinical care of patients with exfoliating skin disease - TENS

  3. Skin bank

  4. HyperbaricOxygen Program

  5. (Partial thickness) Superficial Deep (Full thickness)

  6. Wound Closure • Life-saving - large surface areas, closure ASAP • Cosmetic - life time deficits/defects • Function – joint, tactile, sight, oral

  7. Life-saving Excise &Autograft Excise & Allograft Recrop Autograft Excise & Allograft Recrop Autograft

  8. Life-saving Excise &Autograft Excise & Integra Recrop Autograft Excise & Allograft Recrop Autograft

  9. Integra – Dermal Regeneration Template Collagen, glycosamino- glycan matrix Silastic membrane

  10. Collaboration with School of Chemical and Biomolecular Engineering • Abraham Stroock • Microfluidic wound dressings • Cabodi M et al J. Biomedical Materials Research

  11. Concept – Active Dressing Dressing • vapor barrier • mechanical barrier Inputs Outputs • hydration • sanitation • drug delivery • gene delivery • diagnostics • patient profiling • biochemical analysis Interface flow • biochemical regulation • mechanical stimulation • perfusion of tissue wound bed

  12. Technical Approach: “Soft Lithography” silicone monomer micro-mold micro-molding polymerization release release photo-patterning sealing fluidic connections UV light

  13. Model System

  14. Function – Extraction Extraction

  15. Function – Delivery Delivery

  16. Prototype Active Wound Dressing

  17. Collaboration with College of Human Ecology • C.C. Chu • Department of Fiber Science and Apparel Design

  18. Newly Invented Biodegradable Biomaterials: Poly(ester-amide) (PEA) An example of PEA: amino acids as main building blocks An elastomer: biodegradable rubber band C. C. Chu, et al., US Patent 6,503,538, January 7, 2003

  19. Electrospun PEA Fibrous Mat 1 inch Video insert

  20. SEM Image of 3D Microporous PEA Fibrous Structure PEA control (no GN) PEA w/ GN loaded Fiber diameter: 1/100 – 3/100 of human hair

  21. Collaboration with the Department of Biomedical Engineering • Moonsoo Jin, C.C. Chu • A novel growth factor and matrix mimetic-enhanced biodegradable scaffold for skin tissue engineering

  22. Collaboration with the Department of Biomedical Engineering • Recently funded seed grant • Jin –growth factors, matrix-mimetic production, conjugation and cell culture • Chu – 3 dimensional PEA scaffold design and fabrication • Burn Center – animal laboratory and clinical application

  23. Burn Research Team • Palmer Q. “Joe” Bessey, M.D. • Joe Turkowski, M.D. • Suzanne Schwartz, M.D. • Research co-ordinators: Nicole Alden, RN, MPH Angela Rabbitts, RN, MS

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