Biochemistry & medicine

1. Biochemistry & medicine introduction

2. 1、definition Science concerned with chemical basis of life

3. Science concerned with the chemical constituents of living cells and with the reaction and process that they undergo

4. 2 、 The aim of biochemistry  Describe and explain in molecular term  All chemical process of living cell

5. （1）major objective of biochemistry Complete understanding at the molecular level of all the chemical processes associated with living cells

6.  determine  isolation  analyze

7. (2) Further objective Attempt to understand how life began

8. An appreciation of the biochemistry of less complex form of life is often direct relevance to human biochemistry

9. 3.knowledge of biochemistry is essential to all life science

10. physiology  immunology  pharmacology  pathology  microbiology

11. 4、reciprocal relationship between biochemistry & medicine has stimulated mutual advance

12. * Biochemistry studies have illuminated many aspects of health & disease * the study of various aspects of health & disease has opened up new areas of biochemistry

13. biochemistry Nucleic acid Carbohydrates protein lipid arteriosclerosis Diabetes mellitus Genetic disease Sickle cell anemia medicine

14. 5. Normal biochemical processes are the basis of health

15. Definition of health “Complete physical,mental & social well-being and not merely the absence of disease and infirmity” ------WHO

16. A strictly biochemistry viewpoint about health: The situation in which all of the many thousands of intra & extra cellular reactions that occur in the body are proceeding at the rates commensurate with its maximal survival in the physiological state

17. 6. Biochemical research has impact on nutrition and preventive medicine

18. all disease has a • biochemical basis

19. (1)physical agent: mechanical trauma, extremes of temperature, sudden changes in atmospheric pressure, radiation, electric shock

20. (2)chemical agents: drugs, certain toxic compounds, therapeutic drugs

21. (3)biologic agents: Viruses, Bacteria, Fungi, Higher forms of parasites

22. (4) oxygen lack loss of blood supply, depletion of the oxygen-carrying capacity of theblood, poisoning of the oxidative enzyme

23. (5) genetic disorders: Congenital , molecular

24. (6) immunology reaction Anaphylaxis, Autoimmune disease

25. (7) nutritional imbalances Deficiencies,excesses

26. (8) Endocrine imbalances hormonal deficiencies,excesses

27. 8. Biochemical studies contribute to diagnosis, prognosis & treatment

28. Disease causes scurvy deficiencies of vitamin rickets C,D respectively Arteriosclerosis genetic,dietary environment factors Phenylketonuria mainly mutation in the gene coding phenylalanine hydroxylase

29. Disease causes Cystic fibrosis mutation in the gene coding the CFTR protein Cholera exotoxin of vibrio cholera Diabetes type I genetic and environment factors resulting in deficiency of insulin

30. 9.many biochemical studies illuminate disease mechanisms & disease inspire biochemical research

31. Use example (1) to reveal the fundamental demonstration causes &mechanisms of the genetic of diseases defects in CF (2) to suggest rational use of a diet low in treatment of diseases phenylalanine for the treatment of s phenylketonuria (3) to assist in the diagnosis use of the plasma of specific disease enzyme CK-MB in the diagnosis of myocardial infarction

32. Use example (4)To act as screening use of measurement of tests for the early blood tyrosine or diagnosis of certain diseases TSH in the neonatal diagnosis of congenital hypothyroidism

33. Use example • To assist in monitoring use of the plasma enzyme • the progress of certain ALT in monitoring the • disease progress of infectious • hepatitis (6) To assist in assessing the use of measurement of response of diseases to therapy blood CEA in certain patients who have been treated for cancer of the colon