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Visualization of Clinical Trials CT-eXplorer – Group C

Visualization of Clinical Trials CT-eXplorer – Group C. Clinicians and Trial Designers need to: Locate, retrieve, compare, and contrast trials and subsets of data within the trials Discover errors and problems in data Identify opportunities for new trials. Progress. November 10

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Visualization of Clinical Trials CT-eXplorer – Group C

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  1. Visualization of Clinical TrialsCT-eXplorer – Group C • Clinicians and Trial Designers need to: • Locate, retrieve, compare, and contrast trials and subsets of data within the trials • Discover errors and problems in data • Identify opportunities for new trials

  2. Progress • November 10 • Completion of 2 of projected 4 views (Qualifying Conditions + Eligibility Criteria) • Partially completed Interventions • To do: Outcomes • November 30 • Ahead of schedule here • Dynamic queries and linking are in place

  3. Changes to Design • Learned from user that countries will be represented on a map: • Removed country from prototype • Reduced number of displayed qualifying conditions due to screen limitations • Moved trial selector to own pane

  4. In-Progress Solution

  5. Scenario • Pat is designing a trial for Mother to Child Transmission of HIV…

  6. Considers using Zidovudine and Nevirapine delivered together (treatment) Trial Name During Pregnancy During Labor Post partum A B Connor C D A Davis B A B Guay C A Lallemant B   Zidovudine By Arm  Total Size  Nevirapine  Didanosine  Placebo

  7. Interested in testing from 24 weeks gestation (qualifying conditions)

  8. Must ensure no current immunotherapy (eligibility criteria)

  9. Must ensure no current immunotherapy (eligibility criteria) continued…

  10. Needs to understand risks (outcomes) Trial Name Primary Outcomes A Maternal anemia Infant Anemia B Infant Anemia Connor Maternal neutropia C D Infant Neutropenia A Dabis Infant Mortality Maternal anemia B A Infant Anemia Infant HIV infected Infant Anemia Infant HIV infected B Guay C Infant Anemia Infant HIV infected Maternal anemia Infant Anemia Infant Neutropenia A Lallemant Maternal neutropia Infant Anemia B Birth 1 2 3 4 5 6 7 8 9 Weeks  Maternal anemia  Maternal neutropia   Efficacy Outcomes Maternal mortality  Safety Outcomes  Infant Anemia   Infant Neutropenia Month  Infant Mortality  Week  Infant HIV infected

  11. Challenges • Labels for Eligibility criteria section are not optimal • Much blank space in current approach • Must be very careful with how much we display at one time • Defining query slider behavior must be done with care and user feedback

  12. Thank you!

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