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1. 1. Alzheimer’s disease in a mere blood drop !. Goals and business model. Developing blood biomarkers diagnosis solutions for neurodegenerative diseases Presently focused on Alzheimer’s disease Diagnostic kits Preclinical development of disease modifiers

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1

Alzheimer’s disease in a mere blood drop !

Confidential JB/XR/IHD


Goals and business model
Goals and business model

Developing blood biomarkers diagnosis solutions for neurodegenerative diseases

Presently focused on Alzheimer’s disease

Diagnostic kits

Preclinical development of disease modifiers

Stratification of clinical cohorts

Development of screening tests

Seeking partnerships in the future for

Drug development throught biomarkers detection

Manufacturing and distribution of diagnosis kits and dedicated devices

2

Confidential JB/XR/IHD


Intellectual property
Intellectual Property

5 patents, fully accepted, covering from the chemical synthesis of reagents to diagnosis applications

Covered territory:

Europe : published in France, Germany, United-Kingdom, Eire, Italia, Swiss.

USA and Canada

Israel

Japan , Australia

China, India, and Brazil

3

Confidential JB/XR/IHD


Rationale

Two biomarkers measured :

PKC alteration as a functional biomarker

b-amyloid binding as a specific biomarker

Red blood cells are integrators of any biomarker alteration

Limited life time meaning possibility of treatment’s monitoring

10 ml are enought to perform the assay, less than one drop

Rationale

4

Confidential JB/XR/IHD


5

Applications of our peripheral biomarkers

  • These peripheral biomarkers are validated on :

    • in vitro models (cultured cell lines, primary neuronal cultures)

    • animal models (transgenic mice TASTPM , APP/PS1)

    • Human clinical trials

Confidential JB/XR/IHD


6

Collaborative project with Pixcell Medical

Technology ,

By matching the two technologies,creating the standard for the Point Of Care Diagnosis in Neurology in order ton diagnose and to follow the personalize patient’s treatment

Confidential JB/XR/IHD


7

MARKET

This device is first dedicated to the POC market :

- Neurologists

- Hospitals

For the prupose of :

- Initial Diagnosis

- Treatment monitoring and companion test

Confidential JB/XR/IHD


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